【Research and Results】Sports & Lower Extremity

神戸大学医学部整形外科 Kobe University Orthopaedic Surgery

English サイトマップ
  ホーム Home

黒田良祐 教授 Prof. Ryosuke Kuroda

スタッフ Staff

整形外科教室の歩み Department of Orthopaedic Surgery

研究・業績 Research and Results

臨床研修を希望される方へ To Residents,Fellows,and Student

患者様へご案内 To Patients

同門会専用ページ Exclusive use for Alumni Association

  Research and Results
Japanese

Greeting
Staff
 
Research and Results Sports & Lower Extremity Spine Adults Reconstruction
Orthopaedic Oncology Upper Extremity Trauma Reumatology

Sports Medicine and Lower Extremity Division /
Research
Results

The Kobe University Orthopaedic Sports Medicine and Lower Extremity Division is served by five faculties: Prof. Ryosuke Kuroda, Dr. Takehiko Matsushita, Dr. Yuichi Hoshino, Dr. Noriyuki Kanzaki, and Dr. Daisuke Araki. Our treatment strategy is to restore normal joint function and kinematics by using comprehensive joint preserving techniques, such as ligament reconstruction, osteotomy, meniscal repair, or cartilage repair, including cell therapies. Once injuries occur, our sports medicine experts use the most advanced methods to evaluate and treat injuries in professional, nonprofessional, and recreational athletes of all ages. Our mission is returning patients to an active lifestyle based on our clinical and basic researches.

【Clinical research】


 
  ▲Sports Medicine and Lower Extremity
  Division
(1) Knee joint
Anterior cruciate ligament (ACL) and knee ligament reconstruction
Our division traditionally concentrates on the safe return to sports after ACL or knee ligament injuries. Once ACL is injured, ACL reconstruction is the gold standard for treatment due to its poor self-healing ability. To quantitatively assess knee joint laxity, we have developed the three-dimensional (3-D) electromagnetic measurement system (EMS) in 2004 and used this system to patients with knee ligament injury. This system can evaluate the Lachman and pivot shift tests non-invasively and quantitatively. Based on several biomechanical researches, anatomic double-bundle ACL reconstruction, which reproduces both the anteromedial and posterolateral bundles, is our first choice for patients with ACL injury. In addition, we also have some treatment options, such as bone-patellar tendon-bone graft ACL reconstruction with Kurosaka screws, selective single-bundle ACL reconstruction (ACL remnant preserved augmentation technique) or epiphyseal plate-preserving technique. These clinical researches have led many athletes to undergo surgical treatment in our division.

Articular cartilage injuries
For focal osteochondral lesions or osteochondritis dissecans, we select the treatment strategies, such as arthrosopic bone marrow stimulations (drilling, micro-fracture or abrasion chondroplasty), autogenous osteochondral graft transfer (mosaicplasty), or autologous chondrocyte implantation, based on osteochondral lesion size. To date, we have reported good clinical results of these treatments. For autogenous osteochondral graft transfer, we investigated the ideal matching patterns of articular surface profiles of the donor and recipient sites using a 3-D laser scanning method. For larger traumatic cartilage defects, autologous chondrocyte implantation is the first choice. Since 2012, we conducted the investigator-initiated clinical research of the 3rd generation of this treatment in collaboration with the Institute of Biomedical Research and Innovation Hospital (http://www.ibri-kobe.org/hospital/english/). The good outcome of this clinical research is now stepped onto the sponsor-initiated clinical research. We recently performed the 2nd generation of autologous chondrocyte implantation using JACCR (J-TEC, Japan), with good post-operative outcomes.

Meniscal injuries
To treat meniscal injuries, we are actively performing arthroscopic meniscal repair because meniscectomy leads to a high risk of osteoarthritis. Furthermore, we used fibrin clots for meniscal repair to enhance the clinical results. In animal studies, we reported that platelet-rich plasma (PRP) enhances the healing of meniscal defects. Based on this result, we will also consider clinical trials or either surgical treatments using PRP or intracapsular injection, with the goal of further improving our results.

Patellofemoral joint disorders
Patellar dislocation is a multifactorial problem because patellar stability relies on limb alignment, the osseous structure of the patella and trochlea, and the integrity of static and dynamic soft-tissue constraints. To treat these patellar dislocations, our first choice is medial patellofemoral ligament (MPFL) reconstruction. This technique is an operative procedure independently developed at our division, which has shown good clinical results. Furthermore, by developing 3-D analysis software in collaboration with the Kobe University Faculty of Engineering, we perform motion analysis of normal knees, adding the individual anatomy of each case to preoperative planning, with the aim of further improving postoperative results.

Early-stage osteoarthritis
As the sports population is growing, the importance of joint preservation surgery is highlighted. Recently, we actively select osteotomy, which improves pain and disability from isolated unicompartmental disease in the knee through surgical correction of weight-bearing alignment, as a treatment option for highly active and/or relatively young patients with osteoarthritis. Osteotomy includes distal femur osteotomy, high tibial osteotomy (open-wedge or hybrid), and double-level osteotomy, which combines the previous two procedures. The osteotomy type is selected by the deformity of each case. Our division has used computer navigation systems for obtaining more accurate alignment and advancing the state of our treatments.

(2) Foot and ankle joints
Only few hospitals have expertise on the treatments for foot and ankle surgery because of its specificity in orthopedics. For novel treatment strategies for foot and ankle joints, we aggressively perform not only conservative treatments, but also minimum invasive surgical treatments with the newest implements and surgical techniques.
Ankle lateral ligament injury is one of the most common sports injuries, and several surgical procedures have been developed and gradually spread. We also perform arthroscopic ligament repair (arthroscopic Brostrom procedure) and initiatively use the procedure. This technique can lead athletes to early recovery from the injury, with good clinical results compared with the conventional open technique.
For ankle osteoarthritis, arthroscopic synovectomy, low tibial osteotomy, ankle arthrodesis (open or arthroscopic), and total ankle arthroplasty are selected. We choose the optimal procedure for each patient, considering the degree of deformity, age, and activity. Particularly, total ankle arthroplasty, which requires high-level technique, is also one option in our division.

【Basic research】

(1) Biomechanics

From 2004, 3-D EMS has been established and used for quantitative evaluation of knee laxity during the Lachman and pivot shift tests, which are widely used as manual examination methods for detecting ACL deficiencies and for postoperative evaluations. This system can record the 6 degrees of freedom of knee kinematics data quantitatively and non-invasively. To date, we have applied this system for both research purposes and clinical use. For biomechanical research projects, we are collaborating with the Department of Human and Artificial Intelligent Systems, Graduate School of Engineering, University of Fukui (https://eng.eng.u-fukui.ac.jp/his/). In addition, we have developed the intra-articular ligament tension measurement system, which could detect ACL tension, the finger pressure measurement system wherein sensors are attached on the fingertip, and the system that could measure wall pressure that could record the applied force toward the bone tunnel for ligament reconstruction by embedding sensors. Furthermore, we have developed the software that could semi-automatically extract the bone tunnels after ACL reconstruction, and have investigated the changes over time of the bone tunnels.
We reported these research results at The Japanese Orthopaedic Association (JOA), The Japanese Orthopaedic Society of Knee Arthroscopy and Sports Medicine (JOSKAS), The Japanese Society for Clinical Biomechanics (JSCB), The Japanese Society of Clinical Sports Medicine (JSCSM), The American Association of Orthopaedic Surgeons (AAOS), The Orthopaedic Research Society (ORS), The American Orthopaedic Society for Sports Medicine (AOSSM), The European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA), and The International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS), and we are always trying to improve ligament reconstruction procedures.

(2) Biology

In our division, we collaborate with the Institute for Frontier Life and Medical Sciences, Kyoto University (http://www.frontier.kyoto-u.ac.jp/te02/index-j.php3), researching on meniscus, ligament, and bone regeneration using various growth factors (b-FGF, BMP, G-CSF, statin, platelet-rich-plasma, etc.). We are also conducting collaborative research with the Institute of Biomedical Research and Innovation (http://www.ibri-kobe.org/laboratory/index.html), investigating on the promotion of remodeling of bone and reconstructed anterior cruciate ligament using vascular endothelial progenitor cells (called stem cells in peripheral blood).
With regard to the regeneration and metabolism of cartilage, because SIRT1 (silent information regulator two ortholog 1) is an essential factor for prolonging life span, we focus on SIRT1 that is a histone deacetylase, and analyze the relationship with osteoarthritis.
Since 2015, we have received human adipose-derived regenerative cells from Osaka Medical College and research on the application to bone fracture healing and osteoarthritis treatment.
We have reported these research results at The Orthopaedic Research Society (ORS), The Osteoarthritis Research Society International (OARSI), The International Cartilage Repair Society (ICRS), The Tissue Engineering and Regenerative Medicine International Society (TERMIS), and many other scientific fields.



Greeting
Staff
 
Research and Results Sports & Lower Extremity Spine Adults Reconstruction
Orthopaedic Oncology Upper Extremity Trauma Reumatology

Sports Medicine and Lower Extremity Division /
Results
Research
Original Article

(1) Araki D, Miller RM, Fujimaki Y, Hoshino Y, Musahl V, Debski RE. Effect of tear location on propagation of isolated supraspinatus tendon tears during increasing levels of cyclic loading. J Bone Joint Surg Am. 97(4):273-278, 2016

(2) Takayama K, Matsumoto T, Muratsu H, Ishida K, Araki D, Matsushita T, Kuroda R, Kurosaka M. The influence of posterior tibial slope changes on joint gap and range of motion in unicompartmental knee arthroplasty. Knee 23(3):517-522, 2016

(3) Nakano N, Matsumoto T, Hashimura M, Takayama K, Ishida K, Araki D, Matsushita T, Kuroda R, Kurosaka M. Coronal lower limb alignment in normal knees-a radiographic analysis of 797 normal knee subjects. Knee 23(2):209-213, 2016

(4) Nakano N, Matsumoto T, Muratsu H, Takayama K, Kuroda R, Kurosaka M. Postoperative Knee Flexion Angle Is Affected by Lateral Laxity in Cruciate-Retaining Total Knee Arthroplasty. J Arthroplasty. 2016 Feb;31(2):401-5

(5) Nagai K, Araki D, Matsushita T, Nishizawa Y, Hoshino Y, Matsumoto T, Takayama K, Nakano N, Nagamune K, Kurosaka M, Kuroda R. Biomechanical Function of Anterior Cruciate Ligament Remnants: Quantitative Measurement With a 3-Dimensional. Arthroscopy. 2016 Jul;32(7):1359-66

(6) Chinzei N, Hashimoto S, Fujishiro T, Hayashi S, Kanzaki N, Uchida S, Kuroda R, Kurosaka M. Inflammation and Degeneration in Cartilage Samples from Patients with Femoroacetabular Impingement. J Bone Joint Surg Am. 2016 Jan 20;98(2):135-41

(7) Chinzei N, Kanzaki N, Fujishiro T, Hayashi S, Hashimoto S, Kuroda R, Kurosaka M. Surgical Management of Irreducible Dislocation of the Peroneus Longus Tendon A Case Report J Am Podiatr Med Assoc. 2016 Mar;106(2):121-7

(8) Hayashi S, Hashimoto S, Kanzaki N, Kuroda R, Kurosaka M. Stem anteversion affects periprosthetic bone mineral density after total hip arthroplasty. Hip Int. 2016 May 16;26(3):260-4

(9) Hayashi S, Hashimoto S, Kanzaki N, Kuroda R, Kurosaka M. Daily activity and initial bone mineral density are associated with periprosthetic bone mineral density after total hip arthroplasty. Hip Int. 2016 Mar-Apr;26(2):169-74

(10) Ueda Y, Matsushita T, Araki D, Kida A, Takiguchi K, Shibata Y, Ono K, Ono R, Matsumoto T, Takayama K, Sakai Y, Kurosaka M, Kuroda R. Factors affecting quadriceps strength recovery after anterior cruciate ligament reconstruction with hamstring autografts in athletes. Knee Surg Sports Traumatol Arthrosc. 2016 Aug 23. [Epub ahead of print]

(11) Nishida K, Matsumoto T, Takayama K, Ishida K, Nakano N, Matsushita T, Kuroda R, Kurosaka M. Remaining mild varus limb alignment leads to better clinical outcome in total knee arthroplasty for varus osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2016 Aug 9. [Epub ahead of print]

(12) Zhang S, Matsushita T, Kuroda R, Nishida K, Matsuzaki T, Matsumoto T, Takayama K, Nagai K, Oka S, Tabata Y, Nagamune K, Kurosaka M. Local Administration of Simvastatin Stimulates Healing of an Avascular Meniscus in a Rabbit Model of a Meniscal Defect. Am J Sports Med. 2016 Jul;44(7):1735-43

(13) Matsumoto T, Shibanuma N, Takayama K, Sasaki H, Ishida K, Matsushita T, Kuroda R, Kurosaka M. The influence of intraoperative soft tissue balance on patellar pressure in posterior-stabilized total knee arthroplasty. Knee. 2016 Jun;23(3):540-4

(14) Musahl V, Rahnemai-Azar AA, Costello J, Arner JW, Fu FH, Hoshino Y, Lopomo N, Samuelsson K, Irrgang JJ. The Influence of Meniscal and Anterolateral Capsular Injury on Knee Laxity in Patients With Anterior Cruciate Ligament Injuries. Am J Sports Med. 2016 Dec;44(12):3126-3131

(15) Musahl V, Griffith C, Irrgang JJ, Hoshino Y, Kuroda R, Lopomo N, Zaffagnini S, Samuelsson K, Karlsson J; PIVOT Study Group. Validation of Quantitative Measures of Rotatory Knee Laxity. Am J Sports Med. 2016 Sep;44(9):2393-8

(16) Lopomo N, Signorelli C, Rahnemai-Azar AA, Raggi F, Hoshino Y, Samuelsson K, Musahl V, Karlsson J, Kuroda R, Zaffagnini S; PIVOT Study Group. Analysis of the influence of anaesthesia on the clinical and quantitative assessment of the pivot shift: a multicenter international study. Knee Surg Sports Traumatol Arthrosc. 2016 Apr 19

(17) Kuroda R, Hoshino Y. Electromagnetic tracking of the pivot-shift. Curr Rev Musculoskelet Med. 2016 Jun;9(2):164-9

(18) Muller B, Hofbauer M, Rahnemai-Azar AA, Wolf M, Araki D, Hoshino Y, Araujo P, Debski RE, Irrgang JJ, Fu FH, Musahl V. Development of computer tablet software for clinical quantification of lateral knee compartment translation during the pivot shift test. Comput Methods Biomech Biomed Engin. 2016;19(2):217-28

(19) Hoshino Y, Rothrauff BB, Hensler D, Fu FH, Musahl V. Arthroscopic image distortion-part I: the effect of lens and viewing angles in a 2-dimensional in vitro model. Knee Surg Sports Traumatol Arthrosc. 2016 Jun;24(6):2065-71

(20) Hoshino Y, Rothrauff BB, Hensler D, Fu FH, Musahl V Arthroscopic image distortion-part II: the effect of lens angle and portal location in a 3D knee model. Knee Surg Sports Traumatol Arthrosc. 2016 Jun;24(6):2072-8

(21) Matsumoto T, Hashimura M, Takayama K, Ishida K, Kawakami Y, Matsuzaki T, Nakano N, Matsushita T, Kuroda R, Kurosaka M. A Radiographic Analysis of Alignment of the Lower Extremities -Initiation and Progression of Varus-type Knee Osteoarthritis. Osteoarthritis Cartilage 23(2):217-23, 2015

(22) Matsumoto T, Ishida K, Tsumura N, Nagai K, Muratsu H, Hida Y, Hiranaka T, Kuroda R, Kurosaka M. Treatment of 50 deep infections after total knee arthroplasty. Orthopedics 38(6):e529-35, 2015

(23) Matsumoto T, Takayama K, Muratsu H, Matsushita T, Kuroda R, Kurosaka M. Semimembranosus release reduces tibial internal rotation and flexion angle in cruciate-retaining total knee arthroplasty. J Arthroplasty 30(9):1537-41, 2015

(24) TakayamaK, Matsumoto T, Muratsu H, Uefuji A, Nakano N, Nagai K, Ishida K, Matsushita T, Kuroda R, Kurosaka M. Joint gap assessment with a tensor is useful for the selection of insert thickness in unicompartmental knee arthroplasty. Clin Biomech 30(1):95-9, 2015

(25) Takayama K, Matsumoto T, Muratsu H, Ishida K, Shibanuma N, Araki D, Matsushita T, Kuroda R, Kurosaka M. The tibia first technique with tensor measurement is useful to predict the soft tissue tension after implantation in unicompartmental knee arthroplasty. Int Orthop 39(4): 667-71, 2015

(26) Takayama K, Kawakami Y, Mifune Y, Matsumoto T, Tang Y, Cummins JH, Greco N, Kuroda R, Kurosaka M, Wang B, Fu FH, Huard J. The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation. Biomaterials 60: 9-19, 2015

(27) Nagai K, Muratsu H, Matsumoto T, Takahara S, Kuroda R, Kurosaka M. Influence of Intraoperative Soft Tissue Balance on Postoperative Active Knee Extension in Posterior-Stabilized Total Knee Arthroplasty. J Arthroplasty 30(7):1155-9, 2015

(28) Nagai K, Matsushita T, Matsuzaki T, Takayama K, Matsumoto T, Kuroda R, Kurosaka M. Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthritis Cartilage 23(8):1412-20, 2015

(29) Nagai K, Hoshino Y, Nishizawa Y, Araki D, Matsushita T, Matsumoto T, Takayama K, Kuroda R, Kurosaka M. Quantitative comparison of the pivot shift test results before and after anterior cruciate ligament reconstruction by using the three dimentional electromagnetic measurement system. Knee Surg Sports Traumatol Arthrosc 23(10): 2876-81, 2015

(30) Nakano N, Matsumoto T, Muratsu H, Matsushita T, Takayama K, Matsuzaki T, Kuroda R, Kurosaka M. Results of total knee arthroplasty with NexGen LPS-Flex for osteoarthritis in the valgus knee: a study of 26 patients followed for a minimum of 2 years. Eur J Orthop Surg Traumatol 25(2):375-80, 2015

(31) Kanzaki N, Nishiyama T, Takakura Y, Takakura Y, Fujishiro T, Hayashi S, Hashimoto S, Kuroda R, Kurosaka M. Tibialis spastic varus foot without tarsal coalition: a report of two cases. J Orthop Sci 20(3):551-4, 2015.

(32) Nakano N, Matsumoto T*, Takayama K, Matsushita T, Araki D, Uefuji A, Nagai K, Zhang S, Inokuchi T, Nishida K, Kuroda R, Kurosaka M. Age-healing potential of anterior cruciate ligament remnant-derived cells. Am J Sport Med 43(3): 700-8, 2015

(33) Nakano N, Matsumoto T, Ishida K, Tsumura N, Hiranaka T, Kuroda R, Kurosaka M. Factors influencing the outcome of deep infection following total knee arthroplasty. Knee 22(4): 328-32, 2015

(34) Ishida K, Shibanuma N, Matsumoto T, Sasaki H, Takayama K, Toda A, Kuroda R, Kurosaka M. Factors affecting intraoperative kinematic patterns and flexion angles in navigated total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 23(6):1741-7, 2015

(35) Ishida K, Toda A, Shibanuma N, Matsumoto T, Kuroda R, Kurosaka M. Evaluation of implant alignment in navigated unicompartmental knee arthroplasty: a comparison of 2D and 3D imaging. Acta Orthop Belg 81(4): 654-61, 2015

(36) Kawakami Y, Ii M, Matsumoto T, Kuroda R, Kuroda T, Kwon SM, Kawamoto A, Akimaru H, Mifune Y, Shoji T, Fukui T, Kurosaka M, Asahara T. SDF-1/CXCR4 in Tie2-lineage Cells Inducing Endothelial Progenitor Cells Contribute to Bone Fracture Healing. J Bone Miner Res 30(1):95-105, 2015

(37) Kawakami Y, Matsumoto T, Takayama K, Ishida K, Nakano N, Matsushita T, Kuroda Y, Kuroda R, Kurosaka M. Intermediate-term comparison of cruciate-retaining versus posterior-stabilized total knee arthroplasty using the new knee society scoring system. Orthodedics 38(12):e1127-e1132, 2015

(38) Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Kawamoto A, Ii M, Akimaru H, Kuroda T, Horii M, Yokoyama A, Alev C, Kuroda R, Kurosaka M, Asahara T. Superior Potential of CD34-positive Cells Compared to Total Mononuclear Cells for healing of Nonunion Following Bone Fracture. Cell Transplant 23(7): 1379-93, 2015

(39) Kuroda Y, Ishida K, Matsumoto T, Sasaki H, Matsuzaki T, Oka S, Takayama K, Tei K, Matsushita T, Tsumura N, Kuroda R, Kurosaka M. Fibular axes are not a reliable landmark for tibial mechanical axes of osteoarthritic knees that underwent total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 23(11): 3362-7, 2015

(40) Zhang S, Matsumoto T, Uefuji A, Matsushita T, Takayama K, Araki D, Nakano N, Nagai K, Matsuzaki T, Kuroda R, Kurosaka M. Anterior cruciate ligament remnant tissue harvested within 3-months after injury predicts higher healing potential. BMC Musculoskelet Disord 16(1): 390, 2015

(41) Chinzei N, Kanzaki N, Takakura Y, Takakura Y, Toda A, Fujishiro T, Hayashi S, Hashimoto S, Kuroda R, Kurosaka M. Surgical management of the peroneus quartus muscle for bilateral ankle pain a case report. J Am Podiatr Med Assoc 105(1):85-91, 2015.

(42) Kanzaki N, Nishiyama T, Fujishiro T, Hayash S, Hashimoto S, Kuroda R, Kurosaka M. Flexible hinge silicone implant with or without titanium grommets for arthroplasty of the first metatarsophalangeal joint. J Orthop Surg 22(1):42-5, 2014.

(43) Takayama K, Kawakami Y, Lee S, Greco N, Lavasani M, Mifune Y, Cummins JH, Yurube T, Kuroda R, Kurosaka M, Fu FH, Huard J. Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. J Orthop Res 32(10):1326-32, 2014

(44) Matsuzaki T, Matsushita T, Tabata Y, Saito T, Matsumoto T, Nagai K, Kuroda R, Kurosaka M. Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model. Biomaterials 35(37):9904-11, 2014

(45) Oka S, Matsushita T, Kubo S, Matsumoto T, Tajimi H, Kurosaka M, Kuroda R. Simulation of the optimal femoral insertion site in medial patellofemoral ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 22(10):2364-71, 2014

(46) Araki D, Kuroda R, Matsumoto T, Nagamune K, Matsushita T, Hoshino Y, Oka S, Nishizawa Y, Kurosaka M. Three-dimensional analysis of bone tunnel changes after anatomic double-bundle anterior cruciate ligament reconstruction using multidetector-row computed tomography. Am J Sports Med 42(9):2234-41, 2014

(47) Morishita M, Ishida K, Matsumoto T, Kuroda R, Kurosaka M, Tsumura N. Intraoperative platelet-rich plasma does not improve outcomes of total knee arthroplasty. J Arthroplasty 29(12):2337-41, 2014

(48) Chinzei N, Ishida K, Kuroda R, Matsumoto T, Kubo S, Iguchi T, Chin T, Akisue T, Nishida K, Kurosaka M, Tsumura N. Tibial tubercle osteotomy with screw fixation for total knee arthroplasty. Orthopedics 37(4):e367-73, 2014

(49) Uefuji A, Matsumoto T, Matsushita T, Ueha T, Zhang S, Kurosaka M, Kuroda R. Age-Related Differences in Anterior Cruciate Ligament Remnant Vascular-Derived Cells. Am J Sports Med 42(6):1478-1486, 2014

(50) Matsushita T, Kuroda R, Oka S, Matsumoto T, Takayama K, Kurosaka M. Clinical outcomes of medial patellofemoral ligament reconstruction in patients with an increased tibial tuberosity-trochlear groove distance. Knee Surg Sports Traumatol Arthrosc 22(10):2438-44, 2014

(51) Matsumoto T, Kuroda R, Matsushita T, Araki D, Hoshino Y, Nagamune K, Kurosaka M. Reduction of tunnel enlargement with use of autologous ruptured tissue in anterior cruciate ligament reconstruction: a pilot clinical trial. Arthroscopy 30(4):468-74, 2014

(52) Nishizawa Y, Matsumoto T, Araki D, Nagamune K, Matsushita T, Kurosaka M, Kuroda R. Matching articular surfaces of selected donor and recipient sites for cylindrical osteochondral grafts of the femur: quantitative evaluation using a 3-dimensional laser scanner. Am J Sports Med 42(3):658-64, 2014

(53) Chinzei N, Ishida K, Tsumura N, Matsumoto T, Kitagawa A, Iguchi T, Nishida K, Akisue T, Kuroda R, Kurosaka M. Satisfactory results at 8 years mean follow-up after ADVANCE medial-pivot total knee arthroplasty. Knee 21(2):387-90, 2014

(54) Kuroda R, Matsumoto T, Kawakami Y, Fukui T, Mifune Y, Kurosaka M. Clinical impact of circulating CD34-positive cells on bone regeneration and healing. Tissue Eng Part B Rev 20(3):190-9, 2014

(55) Kuroda R, Matsumoto T, Niikura T, Kawakami Y, Fukui T, Lee SY, Mifune Y, Kawamata S, Fukushima M, Asahara T, Kawamoto A, Kurosaka M. Local transplantation of granulocyte colony stimulating factor-mobilized CD34+ cells for patients with femoral and tibial nonunion: pilot clinical trial. Stem Cells Transl Med 3(1):128-34, 2014

(56) Matsumoto T, Muratsu H, Kawakami Y, Takayama K, Ishida K, Matsushita T, Akisue T, Nishida K, Kuroda R, Kurosaka M. Soft-tissue balancing in total knee arthroplasty: cruciate-retaining versus posterior-stabilised, and measured-resection versus gap technique. Int Orthop. 38(3):531-7, 2014

(57) Sasaki H, Ishida K, Shibanuma N, Tei K, Tateishi H, Toda A, Yamashiro Y, Matsumoto T, Kuroda R, Kurosaka M. Retrospective comparison of three thromboprophylaxis agents, edoxaban, fondaparinux, and enoxaparin, for preventing venous thromboembolism in total knee arthroplasty. Int Orthop 38(3):525-9, 2014

(58) Nagai K, Muratsu H, Matsumoto T, Miya H, Kuroda R, Kurosaka M. Soft tissue balance changes depending on joint distraction force in total knee arthroplasty. J Arthroplasty 29(3):520-4, 2014

(59) Matsuzaki T, Matsumoto T, Kubo S, Muratsu H, Matsushita T, Kawakami Y, Ishida K, Oka S, Kuroda R, Kurosaka M. Tibial internal rotation is affected by lateral laxity in cruciate-retaining total knee arthroplasty: an intraoperative kinematic study using a navigation system and offset-type tensor. Knee Surg Sports Traumatol Arthrosc. 22(3):615-20, 2014

(60) Chinzei N, Ishida K, Matsumoto T, Kuroda Y, Kitagawa A, Kuroda R, Akisue T, Nishida K, Kurosaka M, Tsumura N. Evaluation of patellofemoral joint in ADVANCE Medial-pivot total knee arthroplasty. Int Orthop. 38(3):509-15, 2014

(61) Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann Rheum Dis 73(7):1397-404, 2014

(62) Oka S, Matsumoto T, Muratsu H, Kubo S, Matsushita T, Ishida K, Kuroda R, Kurosaka M. The influence of the tibial slope on intra-operative soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 22(8):1812-8, 2014

(63) Ishida K, Matsumoto T, Tsumura N, Iwakura T, Kubo S, Iguchi T, Akisue T, Nishida K, Kurosaka M, Kuroda R. No difference between double-high insert and medial-pivot insert in TKA. Knee Surg Sports Traumatol Arthrosc. 22(3):576-80, 2014

(64) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kurosaka M, Kuroda R. Joint gap kinematics in unicompartmental knee arthroplasty. Clin Biomech 28(1):29-33, 2013

(65) Mifune Y, Ota S, Takayama K, Hoshino Y, Matsumoto T, Kuroda R, Kurosaka M, Fu FH, Huard J. Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: Results in an animal model. Am J Sport Med 41(2):365-73, 2013

(66) Nishizawa Y, Matsumoto T, Kubo S, Muratsu H, Matsushita T, Oka S, Ishida K, Matsuzaki T, Nishida K, Akisue T, Kuroda R, Kurosaka M. The influence of the patella height on soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty. Int Orthop 37:421-5, 2013

(67) Matsushita T, Sasaki H, Takayama K, Ishida K, Matsumoto T, Kubo S, Matsuzaki T, Nishida K, Kurosaka M, Kuroda R. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes. J Orthop Res 31(4):531-7, 2013

(68) Oka S, Matsumoto T, Matsushita T, Kubo S, Sasaki H, Nishizawa Y, Matsuzaki T, Tabata Y, Kurosaka M, Kuroda R. Local administration of low dose simvastatin-conjugated gelatin hydrogel for tendon-bone healing in anterior cruciate ligament reconstruction. Tissue Eng 19(9-10):1233-43, 2013

(69) Matsuzaki T, Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kawakami Y, Ishida K, Oka S, Kuroda R, Kurosaka M. Kinematic factors affecting postoperative knee flexion after cruciate-retaining total knee arthroplasty. Int Orthop 37(5):803-8, 2013

(70) Mifune Y, Matsumoto T, Ota S, Meszauos LB, Gao X, Li H, Usas A, Gharaibeh B, Fu FH, Huard J. The Effect of Platelet-Rich Plasma on the Regenerative Therapy of Muscle Derived Stem Cells for Articular Cartilage Repair. Osteoarthritis Cartilage 21(1):175-85, 2013

(71) Mifune Y, Matsumoto T, Takayama K, Terada S, Sekiya N, Kuroda R, Kurosaka M, Fu FH, Huard J. Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction. Biomaterials 34(22):5476-87, 2013

(72) Araki D, Kuroda R, Matsushita T, Matsumoto T, Kubo S, Nagamune K, Kurosaka M. Biomechanical analysis of the knee with partial anterior cruciate ligament disruption: Quantitative evaluation using an electromagnetic measurement system. Arthroscopy 29(6):1053-62, 2013

(73) Mifune Y, Matsumoto T, Murasawa S, Kuroda R, Kawamoto A, Shoji T, Kuroda T, Kurosaka M, Asahara T. Potential of CD271+ Derived Stromal Cells for Cartilage Repair. Cell Transplant 22(7):1201-11, 2013

(74) Araki D, Kuroda R, Matsumoto T, Nagamune K, Matsushita T, Kubo S, Oniki Y, Kurosaka M. An Analysis of Surface Profile for Cylindrical Osteochondral Grafts of the Knee Quantitative Evaluation using a Three-Dimentional Laser Scanner-. Knee Surg Sports Traumatol Arthrosc 21(8):1794-800, 2013

(75) Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Kuroda R, Akimaru H, Mifune Y, Shoji T, Fukui T, Asahi M, Kurosaka M, Asahara T. A Small Interfering RNA Targeting Lnk Accelerates Bone Fracture Healing with Early Neovascularization. Lab Invest 93(9): 1036-53, 2013

(76) Nakano N, Matsumoto T, Ishida K, Tsumura N, Kuroda R, Kurosaka M. Long-term subjective outcomes of computer-assisted total knee arthroplasty. Int Orthop 37(10): 1911-5, 2013

(77) Matsumoto T, Kubo S, Muratsu H, Matsushita T, Ishida K, Kawakami Y, Oka S, Matsuzaki T, Kuroda Y, Nishida K, Akisue T, ,Kuroda R, Kurosaka M. Different pattern in gap balancing between the cruciate-retaining and posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 21(10): 2338-45, 2013

(78) Nagai K, Muratsu H, Matsumoto T, Kubo S, Maruo A, Miya H, Kuroda R, Kurosaka M. Influence of intra-operative soft tissue balance on post-operative early recovery of active knee flexion in posterior-stabilized total knee arthroplasty. Int Orthop 37(11):2153-7, 2013

(79) Osawa A, Harner C, Gharaibeh B, Matsumoto T, Mifune Y, Kopf S, Ingham SM, Schreiber V, Usas A, Huard J*. The Use of Blood Vessel-Derived Stem Cells for Meniscal Regeneration and Repair. Med Sci Sports Exerc 45(5):813-23, 2013

(80) Okamoto J, Matsumoto T, Muratsu H, Kurosaka M, Muragaki Y, Iseki H. Robotic tensor device for optimal soft tissue balance in TKA. Conf Proc IEEE Eng Med Biol Soc 6695-8, 2013

(81) Okamoto J, Kumasaka Y, Kawamura K, Matsumoto T, Kubo S, Muratsu H, Kurosaka M, Fujie MG. Study of Anatomical Landmark Sampling Error Effect on Motion Measurement Reproducibility for Orthopaedic Physical Examination Assisting System. Journal of Advanced Mechanical Design, Systems, and Manufacturing

(82) Takayama K, Matsumoto T, Kubo S, Muratsu H, Ishida K, Matsushita T, Kurosaka M, Kuroda R. The Influence of Intra-operative Joint Gap on Post-operative Flexion Angle in Cruciate-retaining Total Knee Arthroplasty. Knee Surg Sports Traumatol Arthrosc 20(3): 532-7, 2012

(83) Kuroda R, Hoshino Y, Araki D, Nishizawa Y, Nagamune K, Matsumoto T, Kubo S, Matsushita T, Kurosaka M. Quantitative measurement of the pivot shift, reliability, and clinical applications. Knee Surg Sports Traumatol Arthroscopy 20(4):686-91, 2012

(84) Matsumoto T, Muratsu H. In Reply; Physiologic knee condition in assessing intraoperative soft tissue balance in total knee arthroplasty. J Arthroplasty 27(4):655-6, 2012

(85) Fujita N, Matsushita T, Ishida K, Sasaki K, Kubo S, Matsumoto T, Kurosaka M, Tabata Y, Kuroda R. An analysis of bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable sponge composed of gelatin and β-tricalcium phosphate. J Tissue Eng Regen Med 6(4):291-8, 2012

(86) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Ishida K, Sasaki H, Oka S, Kurosaka M, Kuroda R. Soft tissue balance using tibia first gap technique with navigation system in cruciate-retaining total knee arthroplasty. Int Orthop 36: 975-80, 2012

(87) Matsumoto T, Ingham SM, Mifune Y, Osawa A, Logor A, Usas A, Kuroda R, Kurosaka M, Fu FH, Huard J. Isolation and Characterization of Anterior Cruciate Ligament Derived Stem Cells. Stem Cells Dev 21(6):859-72, 2012

(88) Matsumoto T, Kubo S, Sasaki K, Kawakami Y, Oka S, Sasaki H, Takayama K, Tei K, Matsushita T, Mifune Y, Kurosaka M, Kuroda R. Acceleration of tendon-bone healing of anterior cruciate ligament graft using autologous ruptured tissue. Am J Sport Med 40(6): 1296-1302, 2012

(89) Sasaki H, Takayama K, Matsushita T, Ishida K, Kubo S, Matsumoto T, Fujita N, Oka S, Kurosaka M, Kuroda R. Autophagy modulates osteoarthritis-related gene expressions in human chondrocytes. Arthritis Rheum 64(6): 1920-8, 2012

(90) Fukui T, Ii M, Shoji T, Matsumoto T, Mifune Y, Kawakami Y, Akimaru H, Kawamoto A, Kuroda T, Saito T, Tabata Y, Kuroda R, Kurosaka M, Asahara T. Therapeutic Effect of Local Administration of Low Dose Simvastatin-conjugated Gelatin Hydrogel for Fracture Healing. J Bone Min Res 27(5):1118-31, 2012

(91) Kawakami Y, Hiranaka T, Matsumoto T, Hida Y, Uemoto H, Tsuji M, Kuroda R, Kurosaka M. Clinical Values of Fluorescopic-Based Navigation System for Anterior Cruciate Ligament Reconstruction. Knee Surg Sports Traumatol Arthrosc 20(8):1503-10, 2012

(92) Oka S, Muratsu H, Matsumoto T, Kubo S, Maruo A, Miya H, Kuroda R, Kurosaka M. The Influence of Patellar Orientation on Soft Tissue Balance in Minimally Incision Total Knee Arthroplasty. Knee Surg Sports Traumatol Arthrosc 20(6):1064-8, 2012

(93) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kurosaka M, Kuroda R. Intra-operative soft tissue balance reflects minimum 5-year mid-term outcomes in cruciate-retaining and posterior-stabilized total knee arthroplasty. J Arthroplasty 27(9):1723-30, 2012

(94) Ishida K, Matsumoto T, Tsumura N, Chinzei N, Kitagawa A, Kubo S, Chin T, Iguchi T, Akisue T, Nishida K, Kurosaka M, Kuroda R. In vivo comparisons of patellofemoral kinematics before and after ADVANCE Medial-Pivot total knee arthroplasty. Int Orthop 36(10): 2073-7, 2012

(95) Fukui T, Matsumoto T, Mifune Y, Shoji T, Kuroda T, Kawakami Y, Kawamoto A, Ii M, Kurosaka M, Asahara T, Kuroda R. Local Transplantation of Granulocyte Colony Stimulating Factor-Mobilized Human Peripheral Blood Mononuclear Cells for Unhealing Bone Fracture. Cell Transplant 21(4):707-21, 2012

(96) Kawakami Y, Ii M, Alev C, Kawamoto A, Matsumoto T, Kuroda R, Shoji T, Fukui T, Masuda H, Akimaru H, Mifune Y, Kuroda T, Horii M, Yokoyama A, Kurosaka M, Asahara T. Local Transplantation of Ex-vivo Expanded Bone Marrow-derived CD34 positive Cells Accelerate Fracture Healing. Cell Transplant 21(12):2689-709, 2012

(97) Lee YH, Kuroda R, Zhao J, Chan KM. A tale of 10 European centres - 2010 APOSSM travelling fellowship review in ACL surgery. Sports Med Arthrosc Rehabil Ther Technol. 2012 Jul 28;4(1):27. doi: 10.1186/1758-2555-4-27.

(98) Nishimori M, Matsumoto T, Ota S, Kopf S, Mifune Y, Harner C, Ochi M, Fu FH, Huard J. Role of angiogenesis after muscle derived stem cell transplantation in injured medial collateral ligament. J Orthop Res 30(4): 627-33, 2012


Case Report


(1) Tsujimoto R, Matsumoto T, Takayama K, Kawakami Y, Kamimura M, Matsushita T, Kuroda R, Kurosaka M. Acute Popliteal Artery Occlusion after Revision Total Knee Arthroplasty. Case Rep Orthop 672164, 2015

(2) Kuroda Y, Matsushita T, Matsumoto T, Kawakami Y, Kurosaka M, Kuroda R. Bilateral medial patellofemoral ligament reconstruction in high-level athletes. Knee Surg Sports Traumatol Arthrosc. 22(10):2465-9, 2014

(3) Matsushita T, Kuroda R, Araki D, Kubo S, Matsushita T, Matsumoto T, Kurosaka M. Medial patellofemoral ligament reconstruction with lateral soft tissue release in adult patients with habitual patellar dislocation. Knee Surg Sports Traumatol Arthrosc 21(3):726-30, 2013

(4) Fujita N, Matsumoto T, Kubo S, Matsushita T, Ishida K, Hoshino Y, Nishimoto K, Kurosaka M, Kuroda R. Autologous osteochondral graft transplantation for steroid-induced osteonecrosis of the femoral condyle: A report of three young cases. Sports Med Arthrosc Rehabil Ther Technol 4(1):13, 2012

(5) Nagai K, Matsumoto T, Matsushita T, Kubo S, Takayama K, Araki D, Sasaki H, Oka S, Akisue T, Kurosaka M, Kuroda R. Spontaneous Recurrent Hemarthrosis of the Knee Joint in the Elderly. A Report of Two Cases. J Orthop Sci 17(5): 649-53, 2012

(6) Minoda M, Matsumoto T, Kubo S, Matsushita T, Takayama K, Kurosaka M, Kuroda R. Multiple huga subchondral cysts associated with pseudogout in the bilateral knees: A case report and review of the literature. J Orthop Sci 17(6): 817-21, 2012

(7) Niikura T, Lee SY, Matsumoto T, Fukui T, Kawakami Y, Akisue T, Kuroda R, Kurosaka M. Backout of the helical blade of proximal femoral nail antirotation and accompanying fracture nonunion. Orthopedics 35(8): e1264-6, 2012

(8) Matsuzaki T, Akisue T, Kishimoto K, Kishimoto S, Imabori M, Hara H, Okada Y, Hitora T, Kuroda R, Kurosaka M, Yamamoto T. Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis. Rheumatol Int 32(6):1691-4, 2012.

(9) Tei K, Kubo S, Matsumoto T, Matsushita T, Matsumoto A, Kurosaka M, Kuroda R. Combined osteochondral fracture of the posterolateral tibial plateau and Segond fracture with anterior cruciate ligament injury in a skeletally immature patient. Knee Surg Sports Traumatol Arthrosc 20(2):252-5, 2012.

(10) Kuroda R, Matsumoto T, Miwa M, Kawamoto A, Mifune Y, Fukui T, Kawakami Y, Niikura T, Lee SY, Oe K, Shoji T, Kuroda T, Horii M, Yokoyama A, Ono T, Koibuchi Y, Kawamata S, Fukushima M, Kurosaka M, Asahara T. Local Transplantation of G-CSF-Mobilized CD34+ Cells in a Patient with Tibial Nonunion: A Case Report. Cell Transplant 20(9): 1491-6, 2011.

(11) Takayama K, Matsushita T, Matsumoto T, Kubo S, Kurosaka M, Kuroda R.. The double ACL sign: an unusual bucket-handle tear of medial meniscus. Knee Surg Sports Traumatol Arthrosc 19(8): 1343-6, 2011

(12) Matsushita T, Kuroda R, Kubo S, Mizuno K, Matsumoto T, Kurosaka M. Total knee arthroplasty combined with medial patellofemoral ligament reconstruction for osteoarthritic knee with preoperative valgus deformity and chronic patellar dislocation. J Arthroplasty 26(3): 505. E17-20, 2011.


Book Chapter

(1) Matsushita T, Kuroda R. ACL Injury and Its Treatment. Chapter 9. "Avulsion fracture of the ACL." ACL Injury and Its Treatment. Ochi M, Shino K, Yasuda K, Kurosaka M (Eds.) Springer. 437-449, 2016

(2) Kuroda R, Matsushita T, Araki D. Physical Examinations and Device Measurements for ACL Deficiency. ACL Injury and Its Treatment. Ochi M, Shino K, Yasuda K, Kurosaka M (Eds.) Springer Japan. 129-137, 2016

(3) Araki D, Matsushita T, Kuroda R. Bone Tunnel Changes After ACL Reconstruction. ACL Injury and Its Treatment. Ochi M, Shino K, Yasuda K, Kurosaka M (Eds.) Springer Japan. 247-266, 2016

(4) Kurosaka M, Kuroda R, Nagai K. Single- Vs. Double-Bundle ACL Reconstruction, ACL Injury and Its Treatment. Ochi M, Shino K, Yasuda K, Kurosaka M (Eds.) Springer Japan. 291-301, 2016

(5) Matsumoto T, Kuroda R. Strategies to Enhance Biological Tendon-Bone Healing in Anterior Cruciate Ligament Reconstruction. ACL Injury and Its Treatment. Ochi M, Shino K, Yasuda K, Kurosaka M (Eds.) Springer Japan. 537-548, 2016

(6) Matsumoto T, Kuroda R. Causes of Pain After Total Knee Replacement -Malposition and Malorientation after Total Knee Replacement-. The Unhappy Total Knee Replacement: A Comprehensive Review and Management Guide. Michael Hirschmann, Roland Becker (Ed), Springer. 165-73, 2015

(7) Zhang S., Oka S., Kuroda R. and Kurosaka M. Anatomy and Biomechanics of Medial Patellofemoral Ligament In: The Patellofemoral Joint -State of the Art in Evaluation and Management-. Springer Berlin Heidelberg. 17-22, 2014

(8) Matsumoto T, Asahara T. Endothelial progenitor cells, Lnk and bone fracture healing. Stem Cells and Bone Tissue Rajkumar Rajendram (Ed), Science Publishers CRC Press, 180-99, 2013

(9) Matsumoto T, Muratsu H, Kubo S, Kurosaka M, Kuroda R. Soft Tissue Balance in Total Knee Arthroplasty, Recent Advances in Hip and Knee Arthroplasty, Samo K. Fokter (Ed.), ISBN: 978-953-307-841-0, InTech, 2012.

(10) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kuroda R, Kurosaka M. Soft tissue balancing with navigation system. Soft Tissue Balancing in Primary Total Knee Arthroplasty, Roberto Rossi (Ed.), Edizioni Minerva Medica Spa, 33-39, 2012.

(11) Kuroda R, Matsushita T. Anatomic double-bundle anterior crucial ligament reconstruction with G-ST. Curr Rev Musculoskelet Med 4(2):57-64, 2011.

 
ページトップ
ページトップ