【Research and Results】Upper Extremity

神戸大学医学部整形外科 Kobe University Orthopaedic Surgery

English サイトマップ
  ホーム Home

黒田良祐 教授 Prof. Ryosuke Kuroda

スタッフ Staff

整形外科教室の歩み Department of Orthopaedic Surgery

研究・業績 Research and Results

臨床研修を希望される方へ To Residents,Fellows,and Student

患者様へご案内 To Patients

同門会専用ページ Exclusive use for Alumni Association

  Research and Results
Japanese

Greeting
Staff
 
Research and Results Sports & Lower Extremity Spine Adults Reconstruction
Orthopaedic Oncology Upper Extremity Trauma Reumatology
Upper Extremity Surgery Division /
Research
Results

 
  ▲Upper Extremity Surgery Division
Three senior staff and four PhD students are conducting basic and clinical research on shoulder, elbow, and hand surgery. The main topics are tendon biology, tendinosis pathology, and its regeneration. We are also interested in outcomes of massive rotator cuff reconstruction using autologous fascia graft and reversed shoulder arthroplasty.

【Clinical Research】

Evaluation of shoulder muscles and tendons using ultrasound
Ultrasonography is a real-time, noninvasive technique to assess muscle and tendon. We are analyzing those structures and biomechanical characteristics under pathological conditions.
Quantification of neuralgic pain
Pain is one of most difficult symptoms assessed subjectively. We are using a pain-quantitating device and analyze its association with other parameters.

【Basic Research】

Pathology of tendon/rotator cuff under aging, oxidative stress
Accumulation of oxidative stress during aging is one of the causes of tendinosis. We are analyzing these factors in in vivo and in vitro tendinosis models.
Rotator cuff regeneration by tissue engineering
Scaffold, growth factor, and stem cells are key factors for successful tendon tissue regeneration. We are focusing on absorbable biomaterial and CELL SHEET to treat massive rotator cuff tears.
Pathology of muscle atrophy
The muscle weakness after nerve or tendon injury negatively affects the clinical outcomes. Analysis of muscle progenitor cell and controlling it is one of the key factors to obtain good clinical results.


Greeting
Staff
 
Research and Results Sports & Lower Extremity Spine Adults Reconstruction
Orthopaedic Oncology Upper Extremity Trauma Reumatology

Upper Extremity Surgery Division /
Results
Research
Original Article

(1) Kokubu T, Mifune Y, Inui A, Kuroda R. Arthroscopic Rotator Cuff Repair With Graft Augmentation of Fascia Lata for Large and Massive Tears. Arthrosc Tech. 2016 Oct 31;5(6):e1235-e1238.

(2) Muto T, Kokubu T, Mifune Y, Inui A, Sakata R, Harada Y, Takase F, Kurosaka M. Effects of platelet-rich plasma and triamcinolone acetonide on interleukin-1s-stimulated human rotator cuff-derived cells. Bone Joint Res. 2016 Dec;5(12):602-609.

(3) Mifune Y, Inui A, Sakata R, Harada Y, Takase F, Kurosaka M, Kokubu T. High-resolution ultrasound in the diagnosis of trigger finger and evaluation of response to steroid injection. Skeletal Radiol. 2016 Dec;45(12):1661-1667.

(4) Takase F, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, Ueda Y, *Kokubu T, Kurosaka M. The effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations. J Orthop Res. 2016 Sep 29. doi: 10.1002/jor.23451.

(5) Inui A, Nishimoto H, Mifune Y, Kokubu T, Sakata R, Kurosaka M. Ultrasound measurement of median nerve cross-sectional area at the inlet and outlet of carpal tunnel after carpal tunnel release compared to electrodiagnostic findings. Arch Orthop Trauma Surg. 2016 Sep;136(9):1325-30.

(6) Harada Y, Mifune Y, Inui A, Sakata R, Muto T, Takase F, Ueda Y, Kataoka T, Kokubu T, Kuroda R, Kurosaka M. Rotator cuff repair using cell sheets derived from human rotator cuff in a rat model. J Orthop Res. 2017 Feb;35(2):289-296. doi: 10.1002/jor.23289

(7) Kawakami Y, Matsumoto T, Mifune Y, Fukui T, Patel KG, Walker GN, Kurosaka M, Kuroda R. Therapeutic Potential of Endothelial Progenitor Cells in the Field of Orthopaedics. Curr Stem Cell Res Ther. 2016 Aug 10.

(8) Nagura I, Kokubu T, Mifune Y, Inui A, Takase F, Ueda Y, Kataoka T, Kurosaka M. Characterization of progenitor cells derived from torn human rotator cuff tendons by gene expression patterns of chondrogenesis, osteogenesis, and adipogenesis. J Orthop Surg Res31(11):40, 2016

(9) Sakata R, Fujioka H, Tomatsuri M, Kokubu T, Mifune Y, Inui A, Kurosaka M. Treatment and Diagnosis of Panner's Disease. A Report of Three Cases. Kobe J Med Sci 61(2):36-39, 2015

(10) Mifune Y, Inui A, Nagura I, Sakata R, Muto T, Harada Y, Takase F, Kurosaka M, Kokubu T. Application of Pain Quantitative Analysis Device for Assessment of Postoperative Pain after Arthroscopic Rotator Cuff Repair. Open Orthop J 15(9):81-83,2015

(11) Muto T, Kokubu T, Mifune Y, Inui A, Sakata R, Harada Y, Takase F, Ueda Y, Kuroda R, Kurosaka M. Can Platelet-Rich Plasma Protect Rat Achilles Tendons From the Deleterious Effects of Triamcinolone Acetonide? Orthop J Sports Med 3(7), 2015.

(12) Sakata R, Kokubu T, Mifune Y, Inui A, Nishimoto H, Fujioka H, Kuroda R, Kurosaka M. A new bioabsorbable cotton-textured synthetic polymer scaffold for osteochondral repair. Int Orthop 38(11): 2413-20, 2014.

(13) Nagura I, Kanatani T, Sumi M, Inui A, Mifune Y, Kokubu T, Kurosaka M. Management of intolerance to casting the upper extremities in claustrophobic patients. ScientificWorldJournal 2014: 803047, 2014.

(14) Muto T, Kokubu T, Mifune Y, Inui A, Harada Y, Yoshifumi, Takase F, Kuroda R, Kurosaka M. Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection. J Orthop Res 32(10): 1297-304, 2014.

(15) Kanatani T, Nagura I, Kurosaka M, Kokubu T, Sumi M. Electrophysiological assessment of carpal tunnel syndrome in elderly patients: one-year follow-up study. J Hand Surg Am 39(11): 2188-91, 2014.

(16) Harada Y, Kokubu T, Mifune Y, Inui A, Sakata R, Muto T, Takase F, Kurosaka M. Dose- and time-dependent effects of triamcinolone acetonide on human rotator cuff-derived cells. Bone Joint Res 3(12): 328-34, 2014.

(17) Muto T, Kokubu T, Mifune Y, Sakata R, Nagura I, Nishimoto H, Harada Y, Nishida K, Kuroda R, Kurosaka M. Platelet-rich plasma protects rotator cuff-derived cells from the deleterious effects of triamcinolone acetonide. J Orthop Res 31(6): 976-82, 2013.

(18) Mifune Y, Ota S, Takayama K, Hoshino Y, Matsumoto T, Kuroda R, Kurosaka M, Fu FH, Huard J. Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: results in an animal model. Am J Sports Med 41(2): 365-73, 2013.

(19) Mifune Y, Matsumoto T, Takayama K, Terada S, Sekiya N, Kuroda R, Kurosaka M, Fu FH, Huard J. Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction. Biomaterials 34(22): 5476-87, 2013.

(20) Mifune Y, Matsumoto T, Takayama K, Ota S, Li H, Meszaros LB, Usas A, Nagamune K, Gharaibeh B, Fu FH, Huard J. The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair. Osteoarthritis Cartilage 21(1): 175-85, 2013.

(21) Mifune Y, Matsumoto T, Murasawa S, Kawamoto A, Kuroda R, Shoji T, Kuroda T, Fukui T, Kawakami Y, Kurosaka M, Asahara T. Therapeutic superiority for cartilage repair by CD271-positive marrow stromal cell transplantation. Cell Transplant 22(7): 1201-11, 2013.

(22) Inui A, Iwakura T, Hari Reddi A. Regulation of lubricin/superficial zone protein by Wnt signalling in bovine synoviocytes. J Tissue Eng Regen Med, 2013.

(23) Sakata R, Kokubu T, Nagura I, Toyokawa N, Inui A, Fujioka H, Kurosaka M. Localization of vascular endothelial growth factor during the early stages of osteochondral regeneration using a bioabsorbable synthetic polymer scaffold. J Orthop Res 30(2): 252-9, 2012.

(24) Nishimoto H, Kokubu T, Inui A, Mifune Y, Nishida K, Fujioka H, Yokota K, Hiwa C, Kurosaka M. Ligament regeneration using an absorbable stent-shaped poly-L-lactic acid scaffold in a rabbit model. Int Orthop 36(11): 2379-86, 2012.

(25) Mifune Y, Matsumoto T, Ota S, Nishimori M, Usas A, Kopf S, Kuroda R, Kurosaka M, Fu FH, Huard J. Therapeutic potential of anterior cruciate ligament-derived stem cells for anterior cruciate ligament reconstruction. Cell Transplant 21(8): 1651-65, 2012.

(26) Kanatani T, Nagura I, Sumi M, Kokubu T, Mifune Y, Nishida K, Kurosaka M. A coincidental anterior interosseous nerve palsy after volar plate fixation of a distal radius fracture diagnosed by 3D-CT. Kobe J Med Sci 58(4): E96-8, 2012.

(27) Inui A, Kokubu T, Mifune Y, Sakata R, Nishimoto H, Nishida K, Akisue T, Kuroda R, Satake M, Kaneko H, Fujioka H. Regeneration of rotator cuff tear using electrospun poly(d,l-Lactide-Co-Glycolide) scaffolds in a rabbit model. Arthroscopy 28(12): 1790-9, 2012.

(28) Inui A, Iwakura T, Reddi AH. Human stem cells and articular cartilage regeneration. Cells 1(4): 994-1009, 2012.


Case Report

(1) Nagura I, Kanatani T, Sumi M, Kokubu T, Kurosaka M. Recurrence of Enchondroma in a Middle Finger after Curettage and Back-filling with Calcium Phosphate Bone Cement: a Case Report. Kobe J Med Sci. 2016 Jun 16;62(1):E19-21.

(2) Mifune Y, Inui A, Takase F, Ueda Y, Shinohara I, Kuroda R, Kokubu T. Two Extension Block Kirschner Wires' Technique for Bony Mallet Thumb. Case Rep Orthop. 2016;2016:8086594.

(3) Inui A, Suzuki T, Kokubu T, Sakata R, Mifune Y, Kurosaka M. Carpal Tunnel Syndrome Caused by Tumoral Calcinosis. Case Rep Orthop.170873, 2015.

(4) Inui A, Kokubu T, Mifune Y. Volar dislocation of index and middle finger carpometacarpal joints: a case report. J Hand Surg Eur 40(1): 99-100, 2015.

(5) Nagura I, Kanatani T, Sumi M, Inui A, Mifune Y, Kokubu T, Kurosaka M. Management of intolerance to casting the upper extremities in claustrophobic patients. ScientificWorldJournal. 2014;2014:803047. doi: 10.1155/2014/803047.

(6) Takase F, Inui A, Mifune Y, Muto T, Harada Y, Kokubu T, Kurosaka M. Concurrent rotator cuff tear and axillary nerve palsy associated with anterior dislocation of the shoulder and large glenoid rim fracture: a "terrible tetrad". Case Rep Orthop : 312968, 2014.

(7) Kanatani T, Fujioka H, Kurosaka M, Nagura I, Sumi M. Delayed electrophysiological recovery after carpal tunnel release for advanced carpal tunnel syndrome: a two-year follow-up study. J Clin Neurophysiol. 2013 Feb;30(1):95-7. doi: 10.1097/WNP.0b013e31827ed839.

(8) Nagura I, Kokubu T, Fujioka H, Mifune Y, Nishida K, Akisue T, Kuroda R, Kurosaka M. Nontraumatic true aneurysm of the superficial palmar arch: a case report. Kobe J Med Sci 58(1): E29-32, 2012.

(9) Mifune Y, Yagi M, Iwasaki Y, Doita M. Pseudoaneurysm of Lumbar Artery following a Vertebral Biopsy: A Case Report. Case Rep Radiol 2012: 127124, 2012.

(10) Kokubu T, Nagura I, Mifune Y, Kurosaka M. Arthroscopic bony bankart repair using double-threaded headless screw: a case report. Case Rep Orthop 2012: 789418, 2012.

 
ページトップ
ページトップ