【Research and Results】Adult Reconstruction

神戸大学医学部整形外科 Kobe University Orthopaedic Surgery

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黒田良祐 教授 Prof. Ryosuke Kuroda

スタッフ Staff

整形外科教室の歩み Department of Orthopaedic Surgery

研究・業績 Research and Results

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  Research and Results
Japanese

Greeting
Staff
 
Research and Results Sports & Lower Extremity Spine Adults Reconstruction
Orthopaedic Oncology Upper Extremity Trauma Reumatology

Division of Adult Reconstruction and Joint Replacement /
Research
Results

Kobe University Orthopaedic Adult Reconstruction and Joint Replacement Division are conducted by five faculties: Dr. Tomoyuki Matsumoto, Dr. Shinya Hayashi, Dr. Shingo Hashimoto, and Dr. Koji Takayama. Our main treatment and research target is osteoarthritis of the knee and hip joints. Therefore, cartilage biology study, such as regenerative medicine and biomechanics study for end-staged osteoarthritis, which needs knee and hip replacement surgery, is mainly focused in our group.

 
  ▲Division of Adult Reconstruction and
 Joint Replacement
【Clinical Research】

(1) Knee Joint
Total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) are mainly performed for end-stage osteoarthritis (OA). To obtain excellent postoperative outcomes, modified navigation system and an original offset-type tensor has been developed.
The modified navigation system enables not only accurate osteotomy, but also 3-D motion analysis. In addition, 3-D preoperative planning software is introduced to improve its accuracy. The offset-type tensor enables the assessment of soft tissue balance throughout range of motion (ROM) in the physiologic knee after TKA, with a reduced patellofemoral (PF) joint and femoral component in place. The accuracy of measurement and clinical relevance of this tensor have been reported, and this tensor has received high praise in Japan and all over the world. Together with this tensor and modified navigation system, accurate osteotomy and appropriate soft tissue balance are now available simultaneously. Furthermore evaluating the relationship between 3-D motion analysis, soft-tissue balance, and postoperative outcomes is possible.
To date, we have reported that intraoperative soft tissue balance is related to postoperative soft tissue balance and clinical outcomes. We have also reported the clinical outcomes with navigation system, patient satisfaction after TKA using the 2011 Knee Society Score (KSS), and the cause and treatment of prosthetic joint infection (PJI).
We have also evaluated the ligament balance in UKA using a tensor developed for UKA and studied the relationship between the ligament balance and postoperative clinical outcomes. In addition, we conducted a large-scale survey of Japanese lower limb alignment and reported changes in lower limb alignment due to age and knee osteoarthritis in the Japanese population
Based on these research results, we are working on further improvement of postoperative outcomes and patient satisfaction.

(2) Hip Joint

Total hip arthroplasty (THA) is established treatment option for painful hip osteoarthritis. Good long-term clinical result is also expected with improvement of implant design, bearing surface, and materials. However, the difference of implant design affects the osteointegration area with the femoral stem, and may have a disadvantage for bone mineral density around the stem. Thus, we have evaluated bone mineral density of the femur after THA and investigated the ideal implant for ideal bearing force to the femur.
For developmental dysplasia of the hip, we are currently using the curved periacetabular osteotomy (CPO). CPO is a low-invasive osteotomy technique for hip abductor muscle with a 9-cm incision, but this technique depends on surgeon's experiences. We are introducing 3-D simulation software and navigation system when performing CPO to standardize this surgical technique.

【Basic Research】

(1) Biomechanics
TKA is performed using the navigation system, tensor system, and 3-D preoperative planning software together. The relationships between preoperative condition, intraoperative evaluation with navigation system and offset type tensor, and postoperative outcomes are examined in the postoperative knee, with more physiological movement and higher flexion. We are also conducting collaborative research with Tokyo Women's Medical University (http://www.twmu.ac.jp/ABMES/FATS/) for developing a robot tensor, which measures soft tissue balance.

(2) Biology

Total joint replacement is an established surgical treatment option for osteoarthritis, but effective conservative treatment option is not established. Our research purpose is to clear the pathology of osteoarthritis and develop an effective treatment option, including drug and/or gene therapy.


Greeting
Staff
 
Research and Results Sports & Lower Extremity Spine Adults Reconstruction
Orthopaedic Oncology Upper Extremity Trauma Reumatology

Division of Adult Reconstruction and Joint Replacement /
Results
Research

Original Article

(1) Hayashi S, Nishiyama T, Hashimoto S, Matsumoto T, Takayama K, Ishida K, Nishida K, Kuroda R: Risk factors for failure of revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device. BMC Musculoskelet Disord 2017, 18(1):382.

(2) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Nishida K, Ishida K, Kuroda R: Stem anteversion mismatch to the anatomical anteversion causes loss of periprosthetic bone density after THA. J Orthop Surg (Hong Kong) 2017, 25(3):2309499017739478.

(3) Hayashi S, Hirata Y, Okamoto D, Kakunai S, Hashimoto S, Takayama K, Matsumoto T, Niikura T, Fujishiro T, Hiranaka T et al: New Proximal Femoral Compaction Blade Provides Strong Antirotation Stability of the Femoral Head. Orthopedics 2017, 40(3):e491-e494.

(4) Hayashi S, Hashimoto S, Takayama K, Matsumoto T, Takebe K, Terashima Y, Kuroda R, Sakai Y, Ishida K, Nishida K: Risk factors for late deep infection after total hip arthroplasty in patients with rheumatoid arthritis. Acta Reumatol Port 2017, 42(2):150-154.

(5) Hayashi S, Hashimoto S, Takayama K, Matsumoto T, Nishida K, Kuroda R: Multiple Revision Surgeries and Acetabular Bone Defect Size May Predict Daily Activity After Revision Total Hip Arthroplasty. J Arthroplasty 2017, 32(5):1606-1611.

(6) Tsubosaka M, Matsumoto T, Takayama K, Nakano N, Kuroda R: Two cases of late medial instability of the knee due to hip disease after total knee arthroplasty. Int J Surg Case Rep 2017, 37:200-204.

(7) Tsubosaka M, Takayama K, Oka S, Muratsu H, Kuroda R, Matsumoto T: Posterior condylar offset influences the intraoperative soft tissue balance during posterior-stabilized total knee arthroplasty. J Orthop Sci 2017, 22(6):1071-1076.

(8) Tsubosaka M, Matsushita T, Kuroda R, Matsumoto T, Kurosaka M: Pseudoaneurysm of the articular branch of the descending genicular artery following double-bundle anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 2017, 25(9):2721-2724.

(9) Tsubosaka M, Ishida K, Sasaki H, Shibanuma N, Kuroda R, Matsumoto T: Effects of Suture and Tourniquet on Intraoperative Kinematics in Navigated Total Knee Arthroplasty. J Arthroplasty 2017, 32(6):1824-1828.

(10) Matsumoto T, Takayama K, Ishida K, Hayashi S, Hashimoto S, Kuroda R: Kinematically aligned total knee arthroplasty: alternative standardized technique? Ann Transl Med 2017, 5(Suppl 1):S10.

(11) Matsumoto T, Takayama K, Ishida K, Hayashi S, Hashimoto S, Kuroda R: Radiological and clinical comparison of kinematically versus mechanically aligned total knee arthroplasty. Bone Joint J 2017, 99-B(5):640-646.

(12) Takayama K, Kawakami Y, Lavasani M, Mu X, Cummins JH, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD et al: mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging. J Orthop Res 2017, 35(7):1375-1382.

(13) Kamada K, Matsumoto T, Takayama K, Araki D, Hashimoto S, Hayashi S, Matsushita T, Kuroda R: Mobile Bearing Total Knee Arthroplasty for Valgus Knee Osteoarthritis with Permanent Patellar Dislocation: A Case Report and Review of the Literature. Case Rep Orthop 2017, 2017:1230412.

(14) Kawakami Y, Matsumoto T, Mifune Y, Fukui T, Patel KG, Walker GN, Kurosaka M, Kuroda R: Therapeutic Potential of Endothelial Progenitor Cells in the Field of Orthopaedics. Curr Stem Cell Res Ther 2017, 12(1):3-13.

(15) Chinzei N, Hashimoto S, Hayashi S, Kanzaki N, Araki D, Kuroda R, Kurosaka M: Consecutive Bilateral Hip Arthroscopy for Symptomatic Bilateral Femoroacetabular Impingement in an Elite Rugby player: A Case Report. J Nippon Med Sch 2017, 84(6):280-285.

(16) Ishida K, Shibanuma N, Matsumoto T, Toda A, Oka S, Kodato K, Takayama K, Kurosaka M, Kuroda R: Tibiofemoral rotational alignment affects flexion angles in navigated posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2017.

(17) Kumabe Y, Lee SY, Waki T, Iwakura T, Takahara S, Arakura M, Kuroiwa Y, Fukui T, Matsumoto T, Matsushita T et al: Triweekly administration of parathyroid hormone (1-34) accelerates bone healing in a rat refractory fracture model. BMC Musculoskelet Disord 2017, 18(1):545.

(18) Matsuzaki T, Matsumoto T, Muratsu H, Ishida K, Takayama K, Nagai K, Nakano N, Nishida K, Kuroda R, Kurosaka M: The contribution of intraoperative medial compartment stability to post-operative knee flexion angle in unicompartmental knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2017, 25(1):272-276.

(19) Kuroda R, Nagai K, Matsushita T, Araki D, Matsumoto T, Takayama K, Kurosaka M: A new quantitative radiographic measurement of patella for patellar instability using the lateral plain radiograph: 'patellar width ratio'. Knee Surg Sports Traumatol Arthrosc 2017, 25(1):123-128.

(20) Matsushita T, Watanabe S, Araki D, Matsumoto T, Takayama K, Kurosaka M, Kuroda R: High tibial osteotomy combined with cancellous bone graft and osteochondral autograft transplantation in a patient with massive osteochondral defects in the medial femoral condyle. J Orthop Surg (Hong Kong) 2017, 25(1):2309499016685016.

(21) Fukuda K, Miura Y, Maeda T, Hayashi S, Kuroda R: Decoy receptor 3 down-regulates centrosomal protein 70 kDa specifically in rheumatoid synovial fibroblasts. Mod Rheumatol 2017:1-6.

(22) Kawakami Y, Takayama K, Matsumoto T, Tang Y, Wang B, Mifune Y, Cummins JH, Warth RJ, Kuroda R, Kurosaka M et al: Anterior Cruciate Ligament-Derived Stem Cells Transduced With BMP2 Accelerate Graft-Bone Integration After ACL Reconstruction. Am J Sports Med 2017, 45(3):584-597.

(23) Inokuchi T, Matsumoto T, Takayama K, Nakano N, Zhang S, Araki D, Matsushita T, Kuroda R: Influence of the Injury-to-Surgery Interval on the Healing Potential of Human Anterior Cruciate Ligament-Derived Cells. Am J Sports Med 2017, 45(6):1359-1369.

(24) Kihara S, Hayashi S, Hashimoto S, Kanzaki N, Takayama K, Matsumoto T, Chinzei N, Iwasa K, Haneda M, Takeuchi K et al: Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation. J Bone Miner Res 2017, 32(5):991-1001.

(25) Matsushita T, Nagai K, Araki D, Tanaka T, Matsumoto T, Nishida K, Kurosaka M, Kuroda R: Factors associated with the status of meniscal tears following meniscal repair concomitant with anterior cruciate ligament reconstruction. Connect Tissue Res 2017, 58(3-4):386-392.

(26) Nishida K, Matsumoto T, Takayama K, Ishida K, Nakano N, Matsushita T, Kuroda R, Kurosaka M: Remaining mild varus limb alignment leads to better clinical outcome in total knee arthroplasty for varus osteoarthritis. Knee Surg Sports Traumatol Arthrosc 2017, 25(11):3488-3494.

(27) Ueda Y, Matsushita T, Araki D, Kida A, Takiguchi K, Shibata Y, Ono K, Ono R, Matsumoto T, Takayama K et al: Factors affecting quadriceps strength recovery after anterior cruciate ligament reconstruction with hamstring autografts in athletes. Knee Surg Sports Traumatol Arthrosc 2017, 25(10):3213-3219.

(28) Tanaka T, Takayama K, Hashimoto S, Kanzaki N, Hayashi S, Kuroda R, Matsumoto T: Radiographic analysis of the lower limbs using the hip-calcaneus line in healthy individuals and in patients with varus knee osteoarthritis. Knee 2017, 24(5):1146-1152.

(29) Nagai K, Muratsu H, Takeoka Y, Tsubosaka M, Kuroda R, Matsumoto T: The Influence of Joint Distraction Force on the Soft-Tissue Balance Using Modified Gap-Balancing Technique in Posterior-Stabilized Total Knee Arthroplasty. J Arthroplasty 2017, 32(10):2995-2999.

(30) Nakano N, Matsumoto T, Hashimura M, Takayama K, Ishida S, Araki D, Matsushita T, Kuroda R, Kurosaka M. Coronal lower limb alignment in normal knees -A radiographic analysis of 797 normal knees-. Knee 23(2):209-13, 2016

(31) Nakano N, Matsumoto T, Muratsu H, Takayama K, Matsushita T, Kuroda R, Kurosaka M. Postoperative knee flexion angle is affected by lateral laxity in cruciate-retaining total knee arthroplasty. J Arthroplasty 31(2):401-5, 2016

(32) Nakano N, Matsumoto T, Muratsu H, Ishida K, Kuroda R, Kurosaka M. Revision Total knee arthroplasty using the modern constrained condylar knee prosthesis. Acta Ortop Brasileira 24(6): 304-8, 2016

(33) Ishida K, Shibanuma N, Matsumoto T, Sasaki H, Takayama Km Matsuzaki T, Tei K, Kuroda R, Kurosaka M. Navigation-based femorotibial rotation pattern correlated with flexion angle after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 24(1):89-95, 2016

(34) Ishida K, Shibanuma N, Matsumoto T, Tei K, Kuroda R, Kurosaka M. Periarticular multimodal drug injection improves post-operative pain and functional recovery after total knee arthroplasty. J Orthop Sci 21(2):178-83, 2016

(35) Ishida K, Shibanuma N, Matsumoto T, Sasaki H, Takayama K, Hiroshima Y, Kuroda R, Kurosaka M.  Navigation-based tibial rotation at 90° of flexion is associated with better range of motion in navigated total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 24(8): 2447-52, 2016

(36) Hayashi S, Hashimoto S, Kanzaki N, Kuroda R, Kurosaka M. Stem anteversion affects periprosthetic bone mineral density after total hip arthroplasty. Hip Int 26(3):260-4, 2016

(37) Hayashi S, Hashimoto S, Kanzaki N, Kuroda R, Kurosaka M. Daily activity and initial bone mineral density are associated with periprosthetic bone mineral density after total hip arthroplasty. Hip Int 26(2): 167-74, 2016

(38) Matsumoto T, Shibanuma N, Takayama K, Sasaki H, Ishida K, Matsushita T, Kuroda R, Kurosaka M. The influence of intraoperative soft tissue balance on patellar pressure in posterior-stabilized total knee arthroplasty. Knee 23(3): 540-4, 2016

(39) Takayama K, Matsumoto T, Muratsu H, Ishida K, Araki D, Matsushita T, Kuroda R, Kurosaka M. The influence of posterior tibial slope changes on joint gap and range of motion in unicompartmental knee arthroplasty. Knee 23(3), 517-22, 2016

(40) Chinzei N, Hashimoto S, Fujishiro T, Hayashi S, Kanzaki N, Uchida S, Kuroda R, Kurosaka M. Inflammation and degeneration in cartilage samples from patients with femoroacetabular impingement. J Bone Joint Surg Am 98(2): 135-41, 2016

(41) Zhang S, Matsushita T, Kuroda R, Nishida K, Matsuzaki T, Matsumoto T, Takayama K, Nagai K, Oka S, Tabata Y, Nagamune K, Kurosaka M. Local Administration of Simvastatin Stimulates Healing of an Avascular Meniscus in a Rabbit Model of a Meniscal Defect. Am J Sports Med 44(7): 1735-43, 2016

(42) Atesok K, Doral MN, Karslson J, Egol KA, Jazrawi LM, Coelho PG, Martinez A, Matsumoto T, Owens BD, Ochi M, Hurwitz SR, Atala A, Fu FH, Lu HH, Rodeo SA. Multilayer scaffolds in orthopaedic tissue engineering. Knee Surg Sports Traumatol Arthrosc 24(7):2365-73, 2016

(43) Nagai K, Araki D, Matsushita T, Nishizawa Y, Hoshino Y, Matsumoto T, Takayama K, Nakano N, Nagamune K, Kurosaka M, Kuroda R. Biomechanical function of anterior cruciate ligament remnants: Quantitative measurement with a three-dimensional electromagnetic measurement system. Arthroscopy 32(7): 1359-66, 2016

(44) Kuroda Y, Matsumoto T, Takayama K, Ishida K, Kuroda R, Kurosaka M. Subjective evaluation before and after total knee arthroplasty using the 2011 Knee Society Score. Knee 23(6):964-967, 2016

(45) Toda A, Ishida K, Matsumoto T, Sasaki H, Takayama K, Kuroda R, Kurosaka M, Shibanuma N. Inaccurate rotational component position in image-free navigated unicompartmental knee arthroplasty. Asia-Pacific Sports Med Arthrosc Rehabil Ther Technol 3:19-24, 2016

(46) Matsumoto T, Hashimura M, Takayama K, Ishida K, Kawakami Y, Matsuzaki T, Nakano N, Matsushita T, Kuroda R, Kurosaka M. A Radiographic Analysis of Alignment of the Lower Extremities -Initiation and Progression of Varus-type Knee Osteoarthritis - Osteoarthritis Cartilage 23(2):217-23, 2015

(47) Matsumoto T, Ishida K, Tsumura N, Nagai K, Muratsu H, Hida Y, Hiranaka T, Kuroda R, Kurosaka M. Treatment of 50 deep infections after total knee arthroplasty. Orthopedics 38(6):e529-35, 2015

(48) Matsumoto T, Takayama K, Muratsu H, Matsushita T, Kuroda R, Kurosaka M. Semimembranosus release reduces tibial internal rotation and flexion angle in cruciate-retaining total knee arthroplasty. J Arthroplasty 30(9):1537-41, 2015

(49) TakayamaK, Matsumoto T, Muratsu H, Uefuji A, Nakano N, Nagai K, Ishida K, Matsushita T, Kuroda R, Kurosaka M. Joint gap assessment with a tensor is useful for the selection of insert thickness in unicompartmental knee arthroplasty. Clin Biomech 30(1):95-9, 2015

(50) Takayama K, Matsumoto T, Muratsu H, Ishida K, Shibanuma N, Araki D, Matsushita T, Kuroda R, Kurosaka M. The tibia first technique with tensor measurement is useful to predict the soft tissue tension after implantation in unicompartmental knee arthroplasty. Int Orthop 39(4): 667-71, 2015

(51) Takayama K, Kawakami Y, Mifune Y, Matsumoto T, Tang Y, Cummins JH, Greco N, Kuroda R, Kurosaka M, Wang B, Fu FH, Huard J. The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation. Biomaterials 60: 9-19, 2015

(52) Nagai K, Muratsu H, Matsumoto T, Takahara S, Kuroda R, Kurosaka M. Influence of Intraoperative Soft Tissue Balance on Postoperative Active Knee Extension in Posterior-Stabilized Total Knee Arthroplasty. J Arthroplasty 30(7):1155-9, 2015

(53) Nagai K, Matsushita T, Matsuzaki T, Takayama K, Matsumoto T, Kuroda R, Kurosaka M. Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in huma chndrocytes. Osteoarthritis Cartilage 23(8):1412-20, 2015

(54) Nagai K, Hoshino Y, Nishizawa Y, Araki D, Matsushita T, Matsumoto T, Takayama K, Kuroda R, Kurosaka M.. Quantitative comparison of the pivot shift test results before and after anterior cruciate ligament reconstruction by using the three dimentional electromagnetic measurement system. Knee Surg Sports Traumatol Arthrosc 23(10): 2876-81, 2015

(55) Nakano N, Matsumoto T, Muratsu H, Matsushita T, Takayama K, Matsuzaki T, Kuroda R, Kurosaka M. Results of total knee arthroplasty with NexGen LPS-Flex for osteoarthritis in the valgus knee: a study of 26 patients followed for a minimum of 2 years. Eur J Orthop Surg Traumatol 25(2):375-80, 2015

(56) Nakano N, Matsumoto T*, Takayama K, Matsushita T, Araki D, Uefuji A, Nagai K, Zhang S, Inokuchi T, Nishida K, Kuroda R, Kurosaka M. Age-healing potential of anterior cruciate ligament remnant-derived cells. Am J Sport Med 43(3): 700-8, 2015

(57) Nakano N, Matsumoto T, Ishida K, Tsumura N, Hiranaka T, Kuroda R, Kurosaka M. Factors influencing the outcome of deep infection following total knee arthroplasty. Knee 22(4): 328-32, 2015

(58) Ishida K, Shibanuma N, Matsumoto T, Sasaki H, Takayama K, Toda A, Kuroda R, Kurosaka M. Factors affecting intraoperative kinematic patterns and flexion angles in navigated total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 23(6):1741-7, 2015

(59) Ishida K, Toda A, Shibanuma N, Matsumoto T, Kuroda R, Kurosaka M. Evaluation of implant alignment in navigated unicompartmental knee arthroplasty : a comparison of 2D and 3D imaging. Acta Orthop Belg 81(4): 654-61, 2015

(60) Kawakami Y, Ii M, Matsumoto T, Kuroda R, Kuroda T, Kwon SM, Kawamoto A, Akimaru H, Mifune Y, Shoji T, Fukui T, Kurosaka M, Asahara T. SDF-1/CXCR4 in Tie2-lineage Cells Inducing Endothelial Progenitor Cells Contribute to Bone Fracture Healing. J Bone Miner Res 30(1):95-105, 2015

(61) Kawakami Y, Matsumoto T, Takayama K, Ishida K, Nakano N, Matsushita T, Kuroda Y, Kuroda R, Kurosaka M. Intermediate-term comparison of cruciate-retaining versus posterior-stabilized total knee arthroplasty using the new knee society scoring system. Orthodedics 38(12):e1127-e1132, 2015

(62) Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Kawamoto A, Ii M, Akimaru H, Kuroda T, Horii M, Yokoyama A, Alev C, Kuroda R, Kurosaka M, Asahara T. Superior Potential of CD34-positive Cells Compared to Total Mononuclear Cells for healing of Nonunion Following Bone Fracture. Cell Transplant 23(7): 1379-93, 2015

(63) Kuroda Y, Ishida K, Matsumoto T, Sasaki H, Matsuzaki T, Oka S, Takayama K, Tei K, Matsushita T, Tsumura N, Kuroda R, Kurosaka M. Fibular axes are not a reliable landmark for tibial mechanical axes of osteoarthritic knees that underwent total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 23(11): 3362-7, 2015

(64) Zhang S, Matsumoto T, Uefuji A, Matsushita T, Takayama K, Araki D, Nakano N, Nagai K, Matsuzaki T, Kuroda R, Kurosaka M. Anterior cruciate ligament remnant tissue harvested within 3-months after injury predicts higher healing potential. BMC Musculoskelet Disord 16(1): 390, 2015

(65) Takayama K, Kawakami Y, Lee S, Greco N, Lavasani M, Mifune Y, Cummins JH, Yurube T, Kuroda R, Kurosaka M, Fu FH, Huard J. Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. J Orthop Res 32(10):1326-32, 2014

(66) Matsuzaki T, Matsushita T, Tabata Y, Saito T, Matsumoto T, Nagai K, Kuroda R, Kurosaka M. Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model. Biomaterials 35(37):9904-11, 2014

(67) Oka S, Matsushita T, Kubo S, Matsumoto T, Tajimi H, Kurosaka M, Kuroda R. Simulation of the optimal femoral insertion site in medial patellofemoral ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 22(10):2364-71, 2014

(68) Araki D, Kuroda R, Matsumoto T, Nagamune K, Matsushita T, Hoshino Y, Oka S, Nishizawa Y, Kurosaka M. Three-dimensional analysis of bone tunnel changes after anatomic double-bundle anterior cruciate ligament reconstruction using multidetector-row computed tomography. Am J Sports Med 42(9):2234-41, 2014

(69) Morishita M, Ishida K, Matsumoto T, Kuroda R, Kurosaka M, Tsumura N. Intraoperative platelet-rich plasma does not improve outcomes of total knee arthroplasty. J Arthroplasty 29(12):2337-41, 2014

(70) Chinzei N, Ishida K, Kuroda R, Matsumoto T, Kubo S, Iguchi T, Chin T, Akisue T, Nishida K, Kurosaka M, Tsumura N. Tibial tubercle osteotomy with screw fixation for total knee arthroplasty. Orthopedics 37(4):e367-73, 2014

(71) Uefuji A, Matsumoto T, Matsushita T, Ueha T, Zhang S, Kurosaka M, Kuroda R. Age-Related Differences in Anterior Cruciate Ligament Remnant Vascular-Derived Cells. Am J Sports Med 42(6):1478-1486, 2014

(72) Matsushita T, Kuroda R, Oka S, Matsumoto T, Takayama K, Kurosaka M. Clinical outcomes of medial patellofemoral ligament reconstruction in patients with an increased tibial tuberosity-trochlear groove distance. Knee Surg Sports Traumatol Arthrosc 22(10):2438-44, 2014

(73) Matsumoto T, Kuroda R, Matsushita T, Araki D, Hoshino Y, Nagamune K, Kurosaka M. Reduction of tunnel enlargement with use of autologous ruptured tissue in anterior cruciate ligament reconstruction: a pilot clinical trial. Arthroscopy 30(4):468-74, 2014

(74) Nishizawa Y, Matsumoto T, Araki D, Nagamune K, Matsushita T, Kurosaka M, Kuroda R. Matching articular surfaces of selected donor and recipient sites for cylindrical osteochondral grafts of the femur: quantitative evaluation using a 3-dimensional laser scanner. Am J Sports Med 42(3):658-64, 2014

(75) Chinzei N, Ishida K, Tsumura N, Matsumoto T, Kitagawa A, Iguchi T, Nishida K, Akisue T, Kuroda R, Kurosaka M. Satisfactory results at 8 years mean follow-up after ADVANCER medial-pivot total knee arthroplasty. Knee 21(2):387-90, 2014

(76) Kuroda R, Matsumoto T, Kawakami Y, Fukui T, Mifune Y, Kurosaka M. Clinical impact of circulating CD34-positive cells on bone regeneration and healing. Tissue Eng Part B Rev 20(3):190-9, 2014

(77) Kuroda R, Matsumoto T, Niikura T, Kawakami Y, Fukui T, Lee SY, Mifune Y, Kawamata S, Fukushima M, Asahara T, Kawamoto A, Kurosaka M. Local transplantation of granulocyte colony stimulating factor-mobilized CD34+ cells for patients with femoral and tibial nonunion: pilot clinical trial. Stem Cells Transl Med 3(1):128-34, 2014

(78) Matsumoto T, Muratsu H, Kawakami Y, Takayama K, Ishida K, Matsushita T, Akisue T, Nishida K, Kuroda R, Kurosaka M. Soft-tissue balancing in total knee arthroplasty: cruciate-retaining versus posterior-stabilised, and measured-resection versus gap technique. Int Orthop. 38(3):531-7, 2014

(79) Sasaki H, Ishida K, Shibanuma N, Tei K, Tateishi H, Toda A, Yamashiro Y, Matsumoto T, Kuroda R, Kurosaka M. Retrospective comparison of three thromboprophylaxis agents, edoxaban, fondaparinux, and enoxaparin, for preventing venous thromboembolism in total knee arthroplasty. Int Orthop 38(3):525-9, 2014

(80) Nagai K, Muratsu H, Matsumoto T, Miya H, Kuroda R, Kurosaka M. Soft tissue balance changes depending on joint distraction force in total knee arthroplasty. J Arthroplasty 29(3):520-4, 2014

(81) Matsuzaki T, Matsumoto T, Kubo S, Muratsu H, Matsushita T, Kawakami Y, Ishida K, Oka S, Kuroda R, Kurosaka M. Tibial internal rotation is affected by lateral laxity in cruciate-retaining total knee arthroplasty: an intraoperative kinematic study using a navigation system and offset-type tensor. Knee Surg Sports Traumatol Arthrosc. 22(3):615-20, 2014

(82) Chinzei N, Ishida K, Matsumoto T, Kuroda Y, Kitagawa A, Kuroda R, Akisue T, Nishida K, Kurosaka M, Tsumura N. Evaluation of patellofemoral joint in ADVANCE Medial-pivot total knee arthroplasty. Int Orthop. 38(3):509-15, 2014

(83) Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann Rheum Dis 73(7):1397-404, 2014

(84) Oka S, Matsumoto T, Muratsu H, Kubo S, Matsushita T, Ishida K, Kuroda R, Kurosaka M. The influence of the tibial slope on intra-operative soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 22(8):1812-8, 2014

(85) Ishida K, Matsumoto T, Tsumura N, Iwakura T, Kubo S, Iguchi T, Akisue T, Nishida K, Kurosaka M, Kuroda R. No difference between double-high insert and medial-pivot insert in TKA. Knee Surg Sports Traumatol Arthrosc. 22(3):576-80, 2014

(86) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kurosaka M, Kuroda R. Joint gap kinematics in unicompartmental knee arthroplasty. Clin Biomech 28(1):29-33, 2013

(87) Mifune Y, Ota S, Takayama K, Hoshino Y, Matsumoto T, Kuroda R, Kurosaka M, Fu FH, Huard J. Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: Results in an animal model. Am J Sport Med 41(2):365-73, 2013

(88) Nishizawa Y, Matsumoto T, Kubo S, Muratsu H, Matsushita T, Oka S, Ishida K, Matsuzaki T, Nishida K, Akisue T, Kuroda R, Kurosaka M. The influence of the patella height on soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty. Int Orthop 37:421-5, 2013

(89) Matsushita T, Sasaki H, Takayama K, Ishida K, Matsumoto T, Kubo S, Matsuzaki T, Nishida K, Kurosaka M, Kuroda R. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes. J Orthop Res 31(4):531-7, 2013

(90) Oka S, Matsumoto T, Matsushita T, Kubo S, Sasaki H, Nishizawa Y, Matsuzaki T, Tabata Y, Kurosaka M, Kuroda R. Local administration of low dose simvastatin-conjugated gelatin hydrogel for tendon-bone healing in anterior cruciate ligament reconstruction. Tissue Eng 19(9-10):1233-43, 2013

(91) Matsuzaki T, Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kawakami Y, Ishida K, Oka S, Kuroda R, Kurosaka M. Kinematic factors affecting postoperative knee flexion after cruciate-retaining total knee arthroplasty. Int Orthop 37(5):803-8, 2013

(92) Mifune Y, Matsumoto T, Ota S, Meszauos LB, Gao X, Li H, Usas A, Gharaibeh B, Fu FH, Huard J. The Effect of Platelet-Rich Plasma on the Regenerative Therapy of Muscle Derived Stem Cells for Articular Cartilage Repair. Osteoarthritis Cartilage 21(1):175-85, 2013

(93) Mifune Y, Matsumoto T, Takayama K, Terada S, Sekiya N, Kuroda R, Kurosaka M, Fu FH, Huard J. Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction. Biomaterials 34(22):5476-87, 2013

(94) Araki D, Kuroda R, Matsushita T, Matsumoto T, Kubo S, Nagamune K, Kurosaka M. Biomechanical analysis of the knee with partial anterior cruciate ligament disruption: Quantitative evaluation using an electromagnetic measurement system. Arthroscopy 29(6):1053-62, 2013

(95) Mifune Y, Matsumoto T, Murasawa S, Kuroda R, Kawamoto A, Shoji T, Kuroda T, Kurosaka M, Asahara T. Potential of CD271+ Derived Stromal Cells for Cartilage Repair. Cell Transplant 22(7):1201-11, 2013

(96) Araki D, Kuroda R, Matsumoto T, Nagamune K, Matsushita T, Kubo S, Oniki Y, Kurosaka M. An Analysis of Surface Profile for Cylindrical Osteochondral Grafts of the Knee -Quantitative Evaluation using a Three-Dimentional Laser Scanner-. Knee Surg Sports Traumatol Arthrosc 21(8):1794-800, 2013

(97) Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Kuroda R, Akimaru H, Mifune Y, Shoji T, Fukui T, Asahi M, Kurosaka M, Asahara T. A Small Interfering RNA Targeting Lnk Accelerates Bone Fracture Healing with Early Neovascularization. Lab Invest 93(9): 1036-53, 2013

(98) Nakano N, Matsumoto T, Ishida K, Tsumura N, Kuroda R, Kurosaka M. Long-term subjective outcomes of computer-assisted total knee arthroplasty. Int Orthop 37(10): 1911-5, 2013

(99) Matsumoto T, Kubo S, Muratsu H, Matsushita T, Ishida K, Kawakami Y, Oka S, Matsuzaki T, Kuroda Y, Nishida K, Akisue T, ,Kuroda R, Kurosaka M. Different pattern in gap balancing between the cruciate-retaining and posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 21(10): 2338-45, 2013

(100) Nagai K, Muratsu H, Matsumoto T, Kubo S, Maruo A, Miya H, Kuroda R, Kurosaka M. Influence of intra-operative soft tissue balance on post-operative early recovery of active knee flexion in posterior-stabilized total knee arthroplasty. Int Orthop 37(11):2153-7, 2013

(101) Osawa A, Harner C, Gharaibeh B, Matsumoto T, Mifune Y, Kopf S, Ingham SM, Schreiber V, Usas A, Huard J*. The Use of Blood Vessel-Derived Stem Cells for Meniscal Regeneration and Repair. Med Sci Sports Exerc 45(5):813-23, 2013

(102) Okamoto J, Matsumoto T, Muratsu H, Kurosaka M, Muragaki Y, Iseki H. Robotic tensor device for optimal soft tissue balance in TKA. Conf Proc IEEE Eng Med Biol Soc 6695-8, 2013


Case Report

(1) Tsujimoto R, Matsumoto T, Takayama K, Kawakami Y, Kamimura M, Matsushita T, Kuroda R, Kurosaka M. Acute Popliteal Artery Occlusion after Revision Total Knee Arthroplasty. Case Rep Orthop 672164, 2015

(2) Kuroda Y, Matsushita T, Matsumoto T, Kawakami Y, Kurosaka M, Kuroda R. Bilateral medial patellofemoral ligament reconstruction in high-level athletes. Knee Surg Sports Traumatol Arthrosc. 22(10):2465-9, 2014

(3) Matsushita T, Kuroda R, Araki D, Kubo S, Matsushita T, Matsumoto T, Kurosaka M. Medial patellofemoral ligament reconstruction with lateral soft tissue release in adult patients with habitual patellar dislocation. Knee Surg Sports Traumatol Arthrosc 21(3):726-30, 2013

(4) Fujita N, Matsumoto T, Kubo S, Matsushita T, Ishida K, Hoshino Y, Nishimoto K, Kurosaka M, Kuroda R. Autologous osteochondral graft transplantation for steroid-induced osteonecrosis of the femoral condyle: A report of three young cases. Sports Med Arthrosc Rehabil Ther Technol 4(1):13, 2012

(5) Nagai K, Matsumoto T, Matsushita T, Kubo S, Takayama K, Araki D, Sasaki H, Oka S, Akisue T, Kurosaka M, Kuroda R. Spontaneous Recurrent Hemarthrosis of the Knee Joint in the Elderly. A Report of Two Cases. J Orthop Sci 17(5): 649-53, 2012

(6) Minoda M, Matsumoto T, Kubo S, Matsushita T, Takayama K, Kurosaka M, Kuroda R. Multiple huga subchondral cysts associated with pseudogout in the bilateral knees: A case report and review of the literature. J Orthop Sci 17(6): 817-21, 2012

(7) Niikura T, Lee SY, Matsumoto T, Fukui T, Kawakami Y, Akisue T, Kuroda R, Kurosaka M. Backout of the helical blade of proximal femoral nail antirotation and accompanying fracture nonunion. Orthopedics 35(8): e1264-6, 2012

(8) Matsuzaki T, Akisue T, Kishimoto K, Kishimoto S, Imabori M, Hara H, Okada Y, Hitora T, Kuroda R, Kurosaka M, Yamamoto T. Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis. Rheumatol Int 32(6):1691-4, 2012.

(9) Tei K, Kubo S, Matsumoto T, Matsushita T, Matsumoto A, Kurosaka M, Kuroda R. Combined osteochondral fracture of the posterolateral tibial plateau and Segond fracture with anterior cruciate ligament injury in a skeletally immature patient. Knee Surg Sports Traumatol Arthrosc 20(2):252-5, 2012.

Book Chapter

(1) Matsumoto T, Kuroda R. Strategies to Enhance Biological Tendon-Bone Healing in Anterior Cruciate Ligament Reconstruction. ACL Injury and Its Treatment Ochi M, Shino K, Yasuda K, Kurosaka M (Eds), Springer, 537-548, 2016

(2) Matsumoto T, Kuroda R. Causes of Pain After Total Knee Replacement -Malposition and Malorientation after Total Knee Replacement-. The Unhappy Total Knee Replacement: A Comprehensive Review and Management Guide. Michael Hirschmann, Roland Becker (Ed), Springer. 165-73, 2015

(3) Zhang S., Oka S., Kuroda R. and Kurosaka M. Anatomy and Biomechanics of Medial Patellofemoral Ligament In: The Patellofemoral Joint -State of the Art in Evaluation and Management-. Springer Berlin Heidelberg. 17-22, 2014

(4) Matsumoto T, Asahara T. Endothelial progenitor cells, Lnk and bone fracture healing. Stem Cells and Bone Tissue Rajkumar Rajendram (Ed), Science Publishers CRC Press, 180-99, 2013

 
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