【研究・業績】上肢

神戸大学医学部整形外科 Kobe University Orthopaedic Surgery

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黒田良祐 教授 Prof. Ryosuke Kuroda

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整形外科教室の歩み Department of Orthopaedic Surgery

研究・業績 Research and Results

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  研究・業績

カテゴリトップ 膝・スポーツ 脊椎 股関節・足
腫瘍 上肢 外傷 リウマチ
上肢/研究
業績

 
  ▲上肢グループ
上肢グループは、3人のスタッフと4人の大学院生で臨床・基礎研究をすすめております。対象となる疾患としては、肩から手指までの上肢全体の疾患や外傷が挙げられます。
肩・肘・手関節のスポーツ障害については、エコーを活用した診断の元に、関節鏡による低侵襲治療と早期復帰に努めており、特に肩腱板断裂については一次修復不能な肩腱板広範囲断裂に対する、大腿筋膜グラフト併用の鏡視下腱板修復に積極的に取り組んでおります。さらに、関節の破壊が高度な症例にはリバース型人工関節置換術などの各種の人工関節置換を行っております。
また末梢神経障害については、マイクロサージャリ―による神経縫合や神経移植術、残存した障害については腱移行による機能再建を行っております。

【臨床研究】
近年のエコー技術の発展に伴い、当グループでもエコーを活用した診断や神経、腱鞘ブロック等を行い、上肢疾患のみならず整形外科全体の様々な疾患の治療成績の向上に寄与したいと考えております。
末梢神経障害における'痛み'や'痺れ'の研究にも取り組んでおり、患者立脚型評価用紙、電気刺激による痛み定量装置(Pain Vision)などによる痛み評価と電気生理学的検査結果の関連性等についても解析を進めております。

【基礎研究】

肩腱板の再生医療をメインテーマとして研究を行っております。腱板断裂部組織より幹細胞の分離・同定に成功し、腱板由来幹細胞培養により作成された細胞シートの研究や、筋膜グラフトによる腱板修復術の治癒過程の研究を行い、断裂した腱板の早期再生を目標として日々研究を行っております。
さらに、腱組織の加齢変性やアンチエイジングに関する研究として、老化関連物質の一つであるAGEs(Advanced Glycation End Products) に注目し、糖化ストレスと腱の脆弱化との関連性の検討や、腱板の老化や脂肪変性に関する分子生物学的研究も進めており、将来的には加齢による腱板の変性断裂を予防できる新たな方法の開発につながることを期待しております。

カテゴリトップ 膝・スポーツ 脊椎 股関節・足
腫瘍 上肢 外傷 リウマチ

上肢/業績
研究

英文原著論文(2012年以降)

(1) Kokubu T, Mifune Y, Inui A, Kuroda R. Arthroscopic Rotator Cuff Repair With Graft Augmentation of Fascia Lata for Large and Massive Tears. Arthrosc Tech. 2016 Oct 31;5(6):e1235-e1238.

(2) Muto T, Kokubu T, Mifune Y, Inui A, Sakata R, Harada Y, Takase F, Kurosaka M. Effects of platelet-rich plasma and triamcinolone acetonide on interleukin-1s-stimulated human rotator cuff-derived cells. Bone Joint Res. 2016 Dec;5(12):602-609.

(3) Mifune Y, Inui A, Sakata R, Harada Y, Takase F, Kurosaka M, Kokubu T. High-resolution ultrasound in the diagnosis of trigger finger and evaluation of response to steroid injection. Skeletal Radiol. 2016 Dec;45(12):1661-1667.

(4) Takase F, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, Ueda Y, *Kokubu T, Kurosaka M. The effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations. J Orthop Res. 2016 Sep 29. doi: 10.1002/jor.23451.

(5) Inui A, Nishimoto H, Mifune Y, Kokubu T, Sakata R, Kurosaka M. Ultrasound measurement of median nerve cross-sectional area at the inlet and outlet of carpal tunnel after carpal tunnel release compared to electrodiagnostic findings. Arch Orthop Trauma Surg. 2016 Sep;136(9):1325-30.

(6) Harada Y, Mifune Y, Inui A, Sakata R, Muto T, Takase F, Ueda Y, Kataoka T, Kokubu T, Kuroda R, Kurosaka M. Rotator cuff repair using cell sheets derived from human rotator cuff in a rat model. J Orthop Res. 2017 Feb;35(2):289-296. doi: 10.1002/jor.23289

(7) Kawakami Y, Matsumoto T, Mifune Y, Fukui T, Patel KG, Walker GN, Kurosaka M, Kuroda R. Therapeutic Potential of Endothelial Progenitor Cells in the Field of Orthopaedics. Curr Stem Cell Res Ther. 2016 Aug 10.

(8) Nagura I, Kokubu T, Mifune Y, Inui A, Takase F, Ueda Y, Kataoka T, Kurosaka M. Characterization of progenitor cells derived from torn human rotator cuff tendons by gene expression patterns of chondrogenesis, osteogenesis, and adipogenesis. J Orthop Surg Res31(11):40, 2016

(9) Sakata R, Fujioka H, Tomatsuri M, Kokubu T, Mifune Y, Inui A, Kurosaka M. Treatment and Diagnosis of Panner's Disease. A Report of Three Cases. Kobe J Med Sci 61(2):36-39, 2015

(10) Mifune Y, Inui A, Nagura I, Sakata R, Muto T, Harada Y, Takase F, Kurosaka M, Kokubu T. Application of Pain Quantitative Analysis Device for Assessment of Postoperative Pain after Arthroscopic Rotator Cuff Repair. Open Orthop J 15(9):81-83,2015

(11) Muto T, Kokubu T, Mifune Y, Inui A, Sakata R, Harada Y, Takase F, Ueda Y, Kuroda R, Kurosaka M. Can Platelet-Rich Plasma Protect Rat Achilles Tendons From the Deleterious Effects of Triamcinolone Acetonide? Orthop J Sports Med 3(7), 2015.

(12) Sakata R, Kokubu T, Mifune Y, Inui A, Nishimoto H, Fujioka H, Kuroda R, Kurosaka M. A new bioabsorbable cotton-textured synthetic polymer scaffold for osteochondral repair. Int Orthop 38(11): 2413-20, 2014.

(13) Nagura I, Kanatani T, Sumi M, Inui A, Mifune Y, Kokubu T, Kurosaka M. Management of intolerance to casting the upper extremities in claustrophobic patients. ScientificWorldJournal 2014: 803047, 2014.

(14) Muto T, Kokubu T, Mifune Y, Inui A, Harada Y, Yoshifumi, Takase F, Kuroda R, Kurosaka M. Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection. J Orthop Res 32(10): 1297-304, 2014.

(15) Kanatani T, Nagura I, Kurosaka M, Kokubu T, Sumi M. Electrophysiological assessment of carpal tunnel syndrome in elderly patients: one-year follow-up study. J Hand Surg Am 39(11): 2188-91, 2014.

(16) Harada Y, Kokubu T, Mifune Y, Inui A, Sakata R, Muto T, Takase F, Kurosaka M. Dose- and time-dependent effects of triamcinolone acetonide on human rotator cuff-derived cells. Bone Joint Res 3(12): 328-34, 2014.

(17) Muto T, Kokubu T, Mifune Y, Sakata R, Nagura I, Nishimoto H, Harada Y, Nishida K, Kuroda R, Kurosaka M. Platelet-rich plasma protects rotator cuff-derived cells from the deleterious effects of triamcinolone acetonide. J Orthop Res 31(6): 976-82, 2013.

(18) Mifune Y, Ota S, Takayama K, Hoshino Y, Matsumoto T, Kuroda R, Kurosaka M, Fu FH, Huard J. Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: results in an animal model. Am J Sports Med 41(2): 365-73, 2013.

(19) Mifune Y, Matsumoto T, Takayama K, Terada S, Sekiya N, Kuroda R, Kurosaka M, Fu FH, Huard J. Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction. Biomaterials 34(22): 5476-87, 2013.

(20) Mifune Y, Matsumoto T, Takayama K, Ota S, Li H, Meszaros LB, Usas A, Nagamune K, Gharaibeh B, Fu FH, Huard J. The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair. Osteoarthritis Cartilage 21(1): 175-85, 2013.

(21) Mifune Y, Matsumoto T, Murasawa S, Kawamoto A, Kuroda R, Shoji T, Kuroda T, Fukui T, Kawakami Y, Kurosaka M, Asahara T. Therapeutic superiority for cartilage repair by CD271-positive marrow stromal cell transplantation. Cell Transplant 22(7): 1201-11, 2013.

(22) Inui A, Iwakura T, Hari Reddi A. Regulation of lubricin/superficial zone protein by Wnt signalling in bovine synoviocytes. J Tissue Eng Regen Med, 2013.

(23) Sakata R, Kokubu T, Nagura I, Toyokawa N, Inui A, Fujioka H, Kurosaka M. Localization of vascular endothelial growth factor during the early stages of osteochondral regeneration using a bioabsorbable synthetic polymer scaffold. J Orthop Res 30(2): 252-9, 2012.

(24) Nishimoto H, Kokubu T, Inui A, Mifune Y, Nishida K, Fujioka H, Yokota K, Hiwa C, Kurosaka M. Ligament regeneration using an absorbable stent-shaped poly-L-lactic acid scaffold in a rabbit model. Int Orthop 36(11): 2379-86, 2012.

(25) Mifune Y, Matsumoto T, Ota S, Nishimori M, Usas A, Kopf S, Kuroda R, Kurosaka M, Fu FH, Huard J. Therapeutic potential of anterior cruciate ligament-derived stem cells for anterior cruciate ligament reconstruction. Cell Transplant 21(8): 1651-65, 2012.

(26) Kanatani T, Nagura I, Sumi M, Kokubu T, Mifune Y, Nishida K, Kurosaka M. A coincidental anterior interosseous nerve palsy after volar plate fixation of a distal radius fracture diagnosed by 3D-CT. Kobe J Med Sci 58(4): E96-8, 2012.

(27) Inui A, Kokubu T, Mifune Y, Sakata R, Nishimoto H, Nishida K, Akisue T, Kuroda R, Satake M, Kaneko H, Fujioka H. Regeneration of rotator cuff tear using electrospun poly(d,l-Lactide-Co-Glycolide) scaffolds in a rabbit model. Arthroscopy 28(12): 1790-9, 2012.

(28) Inui A, Iwakura T, Reddi AH. Human stem cells and articular cartilage regeneration. Cells 1(4): 994-1009, 2012.


英文症例報告(2012年以降)

(1) Nagura I, Kanatani T, Sumi M, Kokubu T, Kurosaka M. Recurrence of Enchondroma in a Middle Finger after Curettage and Back-filling with Calcium Phosphate Bone Cement: a Case Report. Kobe J Med Sci. 2016 Jun 16;62(1):E19-21.

(2) Mifune Y, Inui A, Takase F, Ueda Y, Shinohara I, Kuroda R, Kokubu T. Two Extension Block Kirschner Wires' Technique for Bony Mallet Thumb. Case Rep Orthop. 2016;2016:8086594.

(3) Inui A, Suzuki T, Kokubu T, Sakata R, Mifune Y, Kurosaka M. Carpal Tunnel Syndrome Caused by Tumoral Calcinosis. Case Rep Orthop.170873, 2015.

(4) Inui A, Kokubu T, Mifune Y. Volar dislocation of index and middle finger carpometacarpal joints: a case report. J Hand Surg Eur 40(1): 99-100, 2015.

(5) Nagura I, Kanatani T, Sumi M, Inui A, Mifune Y, Kokubu T, Kurosaka M. Management of intolerance to casting the upper extremities in claustrophobic patients. ScientificWorldJournal. 2014;2014:803047. doi: 10.1155/2014/803047.

(6) Takase F, Inui A, Mifune Y, Muto T, Harada Y, Kokubu T, Kurosaka M. Concurrent rotator cuff tear and axillary nerve palsy associated with anterior dislocation of the shoulder and large glenoid rim fracture: a "terrible tetrad". Case Rep Orthop : 312968, 2014.

(7) Kanatani T, Fujioka H, Kurosaka M, Nagura I, Sumi M. Delayed electrophysiological recovery after carpal tunnel release for advanced carpal tunnel syndrome: a two-year follow-up study. J Clin Neurophysiol. 2013 Feb;30(1):95-7. doi: 10.1097/WNP.0b013e31827ed839.

(8) Nagura I, Kokubu T, Fujioka H, Mifune Y, Nishida K, Akisue T, Kuroda R, Kurosaka M. Nontraumatic true aneurysm of the superficial palmar arch: a case report. Kobe J Med Sci 58(1): E29-32, 2012.

(9) Mifune Y, Yagi M, Iwasaki Y, Doita M. Pseudoaneurysm of Lumbar Artery following a Vertebral Biopsy: A Case Report. Case Rep Radiol 2012: 127124, 2012.

(10) Kokubu T, Nagura I, Mifune Y, Kurosaka M. Arthroscopic bony bankart repair using double-threaded headless screw: a case report. Case Rep Orthop 2012: 789418, 2012.

 
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