【研究・業績】下肢人工関節・関節機能再建

神戸大学医学部整形外科 Kobe University Orthopaedic Surgery

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黒田良祐 教授 Prof. Ryosuke Kuroda

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整形外科教室の歩み Department of Orthopaedic Surgery

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  研究・業績

カテゴリトップ 膝・スポーツ 脊椎 股関節・足
腫瘍 上肢 外傷 リウマチ

下肢人工関節・関節機能再建/研究
業績

 
  ▲下肢人工関節・関節機能再建グループ
【臨床研究】

(1) 膝関節
末期変形性膝関節症に対し、人工膝関節全置換術あるいは単顆型人工膝関節置換術を行っています。良好な術後成績を得るためには、正確な骨切り・コンポーネントの設置および適切な軟部組織バランスの獲得が重要とされています。正確な骨切り・コンポーネントの設置に関しては、Navigation systemを導入・3次元運動を容易に計測できるように独自に改良し、また3次元術前計画ソフトウェアを導入し、その正確性を向上させています。適切な軟部組織バランスの獲得に関しては、独自のtensorを開発し、術中の軟部バランスを評価・調整しています。このtensorは大腿骨コンポーネントを装着し、膝伸展機構を修復し、術後膝を再現した状態で軟部組織バランスを評価できるtensorであり、国内外で高い評価を受けています。現在ではこのtensor systemとnavigation systemを同時に併用することで、正確な骨切り・コンポーネントの設置および適切な軟部組織バランスの獲得が同時に得られるようになり、さらに3次元運動と術後成績、また術中のパラメータとの関係と評価することが可能となっております。これまで、我々は人工膝関節全置換術における手術中の靭帯バランスが術後の靭帯バランスや関節可動域と関係すること、Navigation systemの臨床成績、術後の満足度、術後感染の原因や治療成績などを報告してまいりました。単顆型人工膝関節置換術においても独自に開発したtensorにて靭帯バランスを評価し、術後の臨床成績との関係を研究しております。また、日本人の下肢アライメントの大規模調査を行い、年齢による変化や変形性膝関節症による変化など日本人の特徴を報告しております。これらの研究成果をふまえて、人工膝関節置換術を受けられる患者さまの術後成績の向上、満足度のさらなる向上を目指しています。

(2) 股関節
変形性股関節症に対する人工股関節全置換術は優れた除痛効果など安定した治療成績が期待されます。またインプラントデザインや慴動面の改良、材質の向上など長期成績についても良好な結果が期待されております。しかしながら、インプラントデザインによる固着部位の相違によりインプラント周囲の骨密度が低下する問題点が指摘されております。そこで人工股関節全置換術後から大腿骨を中心とした骨密度を測定し、より生理的な荷重伝達を可能とするインプラントの選択等、治療成績向上に向けて研究を行っています。

寛骨臼形成不全に対する骨切り手術(寛骨臼回転骨切り術)では、Cerved Periacetabular Osteotomy(CPO)を採用して治療に当たっております。この術式では皮切が9cmであり股関節外転筋力への影響が極めて低いことから低侵襲手術であると考えられる一方、骨切り線や寛骨臼の回転方向・量を術者の経験などに頼ることが問題点でした。そこで現在、3Dシュミレーションソフトならびにナビゲーションを併用して手術を行っております。適切な骨切り線や荷重環境の獲得、さらに手術成績の標準化を目指しています。

【基礎研究】

(1) Biomechanics
人工膝関節においては、Navigation system、Tensor systemを併用した手術、2D-3D image matching techniqueを用いて三次元解析ソフトを用いて人工膝関節の3次元動作解析を行い、同時に術前パラメータ・術中操作・術中パラメ-タ・術後成績の関連を解析し、より生理的に動く、そしてより曲がる膝を目指して研究しています。また、東京女子医科大学 先端生命医科学研究所(http://www.twmu.ac.jp/ABMES/FATS/)と共同研究を行っており、軟部組織バランス測定ロボットテンサーを開発中です。

(2) Biology 変形性股関節症における軟骨損傷の病態解明
変形性関節症に対する手術的治療として人工関節置換術は非常に良好な成績を収め、確立されたものとなっていますが、有効な保存的治療(内服、遺伝子治療等)は確立されておりません。よって我々は軟骨変性に対し、病態の解明ならびに薬物ならびに遺伝子治療を開発することを研究の目的としております。 変形性関節症の発症にはさまざまな遺伝子が関与しており、我々はその中で癌抑制遺伝子であるp53さらにp53関連分子のp38 MAPK, p53R2 が関与するという非常に興味深い新しい知見を得ました。その後p53に関連してp21, PTENなどの分子に着目し変形性関節症の病態解明および進行予防を含めた軟骨治療戦略への応用につなげていきたいと思っております。


これらの研究成果を日本整形外科学会、日本整形外科基礎学術集会、日本人工関節学会、日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)、日本股関節学会、日本臨床バイオメカニクス学会、日本CAOS (Computer Assisted Orthopaedic Surgery)研究会、日本軟骨代謝学会、アメリカ整形外科学会(AAOS)、国際人工関節技術学会(ISTA)、International Congress for Joint Reconstruction (ICJR)、Computer Assisted Orthopaedic Surgery (CAOS) International、国際関節鏡・膝・スポーツ整形外科学会(ISAKOS)、アメリカ整形外科基礎学会(ORS)等で報告し、新たな人工関節の開発を目指しています。


カテゴリトップ 膝・スポーツ 脊椎 股関節・足
腫瘍 上肢 外傷 リウマチ

下肢人工関節・関節機能再建/業績
研究

英文原著論文(2012年以降)


(1) Nakano N, Matsumoto T, Hashimura M, Takayama K, Ishida S, Araki D, Matsushita T, Kuroda R, Kurosaka M. Coronal lower limb alignment in normal knees -A radiographic analysis of 797 normal knees-. Knee 23(2):209-13, 2016

(2) Nakano N, Matsumoto T, Muratsu H, Takayama K, Matsushita T, Kuroda R, Kurosaka M. Postoperative knee flexion angle is affected by lateral laxity in cruciate-retaining total knee arthroplasty. J Arthroplasty 31(2):401-5, 2016

(3) Nakano N, Matsumoto T, Muratsu H, Ishida K, Kuroda R, Kurosaka M. Revision Total knee arthroplasty using the modern constrained condylar knee prosthesis. Acta Ortop Brasileira 24(6): 304-8, 2016

(4) Ishida K, Shibanuma N, Matsumoto T, Sasaki H, Takayama Km Matsuzaki T, Tei K, Kuroda R, Kurosaka M. Navigation-based femorotibial rotation pattern correlated with flexion angle after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 24(1):89-95, 2016

(5) Ishida K, Shibanuma N, Matsumoto T, Tei K, Kuroda R, Kurosaka M. Periarticular multimodal drug injection improves post-operative pain and functional recovery after total knee arthroplasty. J Orthop Sci 21(2):178-83, 2016

(6) Ishida K, Shibanuma N, Matsumoto T, Sasaki H, Takayama K, Hiroshima Y, Kuroda R, Kurosaka M.  Navigation-based tibial rotation at 90° of flexion is associated with better range of motion in navigated total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 24(8): 2447-52, 2016

(7) Hayashi S, Hashimoto S, Kanzaki N, Kuroda R, Kurosaka M. Stem anteversion affects periprosthetic bone mineral density after total hip arthroplasty. Hip Int 26(3):260-4, 2016

(8) Hayashi S, Hashimoto S, Kanzaki N, Kuroda R, Kurosaka M. Daily activity and initial bone mineral density are associated with periprosthetic bone mineral density after total hip arthroplasty. Hip Int 26(2): 167-74, 2016

(9) Matsumoto T, Shibanuma N, Takayama K, Sasaki H, Ishida K, Matsushita T, Kuroda R, Kurosaka M. The influence of intraoperative soft tissue balance on patellar pressure in posterior-stabilized total knee arthroplasty. Knee 23(3): 540-4, 2016

(10) Takayama K, Matsumoto T, Muratsu H, Ishida K, Araki D, Matsushita T, Kuroda R, Kurosaka M. The influence of posterior tibial slope changes on joint gap and range of motion in unicompartmental knee arthroplasty. Knee 23(3), 517-22, 2016

(11) Chinzei N, Hashimoto S, Fujishiro T, Hayashi S, Kanzaki N, Uchida S, Kuroda R, Kurosaka M. Inflammation and degeneration in cartilage samples from patients with femoroacetabular impingement. J Bone Joint Surg Am 98(2): 135-41, 2016

(12) Zhang S, Matsushita T, Kuroda R, Nishida K, Matsuzaki T, Matsumoto T, Takayama K, Nagai K, Oka S, Tabata Y, Nagamune K, Kurosaka M. Local Administration of Simvastatin Stimulates Healing of an Avascular Meniscus in a Rabbit Model of a Meniscal Defect. Am J Sports Med 44(7): 1735-43, 2016

(13) Atesok K, Doral MN, Karslson J, Egol KA, Jazrawi LM, Coelho PG, Martinez A, Matsumoto T, Owens BD, Ochi M, Hurwitz SR, Atala A, Fu FH, Lu HH, Rodeo SA. Multilayer scaffolds in orthopaedic tissue engineering. Knee Surg Sports Traumatol Arthrosc 24(7):2365-73, 2016

(14) Nagai K, Araki D, Matsushita T, Nishizawa Y, Hoshino Y, Matsumoto T, Takayama K, Nakano N, Nagamune K, Kurosaka M, Kuroda R. Biomechanical function of anterior cruciate ligament remnants: Quantitative measurement with a three-dimensional electromagnetic measurement system. Arthroscopy 32(7): 1359-66, 2016

(15) Kuroda Y, Matsumoto T, Takayama K, Ishida K, Kuroda R, Kurosaka M. Subjective evaluation before and after total knee arthroplasty using the 2011 Knee Society Score. Knee 23(6):964-967, 2016

(16) Toda A, Ishida K, Matsumoto T, Sasaki H, Takayama K, Kuroda R, Kurosaka M, Shibanuma N. Inaccurate rotational component position in image-free navigated unicompartmental knee arthroplasty. Asia-Pacific Sports Med Arthrosc Rehabil Ther Technol 3:19-24, 2016

(17) Matsumoto T, Hashimura M, Takayama K, Ishida K, Kawakami Y, Matsuzaki T, Nakano N, Matsushita T, Kuroda R, Kurosaka M. A Radiographic Analysis of Alignment of the Lower Extremities -Initiation and Progression of Varus-type Knee Osteoarthritis - Osteoarthritis Cartilage 23(2):217-23, 2015

(18) Matsumoto T, Ishida K, Tsumura N, Nagai K, Muratsu H, Hida Y, Hiranaka T, Kuroda R, Kurosaka M. Treatment of 50 deep infections after total knee arthroplasty. Orthopedics 38(6):e529-35, 2015

(19) Matsumoto T, Takayama K, Muratsu H, Matsushita T, Kuroda R, Kurosaka M. Semimembranosus release reduces tibial internal rotation and flexion angle in cruciate-retaining total knee arthroplasty. J Arthroplasty 30(9):1537-41, 2015

(20) TakayamaK, Matsumoto T, Muratsu H, Uefuji A, Nakano N, Nagai K, Ishida K, Matsushita T, Kuroda R, Kurosaka M. Joint gap assessment with a tensor is useful for the selection of insert thickness in unicompartmental knee arthroplasty. Clin Biomech 30(1):95-9, 2015

(21) Takayama K, Matsumoto T, Muratsu H, Ishida K, Shibanuma N, Araki D, Matsushita T, Kuroda R, Kurosaka M. The tibia first technique with tensor measurement is useful to predict the soft tissue tension after implantation in unicompartmental knee arthroplasty. Int Orthop 39(4): 667-71, 2015

(22) Takayama K, Kawakami Y, Mifune Y, Matsumoto T, Tang Y, Cummins JH, Greco N, Kuroda R, Kurosaka M, Wang B, Fu FH, Huard J. The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation. Biomaterials 60: 9-19, 2015

(23) Nagai K, Muratsu H, Matsumoto T, Takahara S, Kuroda R, Kurosaka M. Influence of Intraoperative Soft Tissue Balance on Postoperative Active Knee Extension in Posterior-Stabilized Total Knee Arthroplasty. J Arthroplasty 30(7):1155-9, 2015

(24) Nagai K, Matsushita T, Matsuzaki T, Takayama K, Matsumoto T, Kuroda R, Kurosaka M. Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in huma chndrocytes. Osteoarthritis Cartilage 23(8):1412-20, 2015

(25) Nagai K, Hoshino Y, Nishizawa Y, Araki D, Matsushita T, Matsumoto T, Takayama K, Kuroda R, Kurosaka M.. Quantitative comparison of the pivot shift test results before and after anterior cruciate ligament reconstruction by using the three dimentional electromagnetic measurement system. Knee Surg Sports Traumatol Arthrosc 23(10): 2876-81, 2015

(26) Nakano N, Matsumoto T, Muratsu H, Matsushita T, Takayama K, Matsuzaki T, Kuroda R, Kurosaka M. Results of total knee arthroplasty with NexGen LPS-Flex for osteoarthritis in the valgus knee: a study of 26 patients followed for a minimum of 2 years. Eur J Orthop Surg Traumatol 25(2):375-80, 2015

(27) Nakano N, Matsumoto T*, Takayama K, Matsushita T, Araki D, Uefuji A, Nagai K, Zhang S, Inokuchi T, Nishida K, Kuroda R, Kurosaka M. Age-healing potential of anterior cruciate ligament remnant-derived cells. Am J Sport Med 43(3): 700-8, 2015

(28) Nakano N, Matsumoto T, Ishida K, Tsumura N, Hiranaka T, Kuroda R, Kurosaka M. Factors influencing the outcome of deep infection following total knee arthroplasty. Knee 22(4): 328-32, 2015

(29) Ishida K, Shibanuma N, Matsumoto T, Sasaki H, Takayama K, Toda A, Kuroda R, Kurosaka M. Factors affecting intraoperative kinematic patterns and flexion angles in navigated total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 23(6):1741-7, 2015

(30) Ishida K, Toda A, Shibanuma N, Matsumoto T, Kuroda R, Kurosaka M. Evaluation of implant alignment in navigated unicompartmental knee arthroplasty : a comparison of 2D and 3D imaging. Acta Orthop Belg 81(4): 654-61, 2015

(31) Kawakami Y, Ii M, Matsumoto T, Kuroda R, Kuroda T, Kwon SM, Kawamoto A, Akimaru H, Mifune Y, Shoji T, Fukui T, Kurosaka M, Asahara T. SDF-1/CXCR4 in Tie2-lineage Cells Inducing Endothelial Progenitor Cells Contribute to Bone Fracture Healing. J Bone Miner Res 30(1):95-105, 2015

(32) Kawakami Y, Matsumoto T, Takayama K, Ishida K, Nakano N, Matsushita T, Kuroda Y, Kuroda R, Kurosaka M. Intermediate-term comparison of cruciate-retaining versus posterior-stabilized total knee arthroplasty using the new knee society scoring system. Orthodedics 38(12):e1127-e1132, 2015

(33) Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Kawamoto A, Ii M, Akimaru H, Kuroda T, Horii M, Yokoyama A, Alev C, Kuroda R, Kurosaka M, Asahara T. Superior Potential of CD34-positive Cells Compared to Total Mononuclear Cells for healing of Nonunion Following Bone Fracture. Cell Transplant 23(7): 1379-93, 2015

(34) Kuroda Y, Ishida K, Matsumoto T, Sasaki H, Matsuzaki T, Oka S, Takayama K, Tei K, Matsushita T, Tsumura N, Kuroda R, Kurosaka M. Fibular axes are not a reliable landmark for tibial mechanical axes of osteoarthritic knees that underwent total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 23(11): 3362-7, 2015

(35) Zhang S, Matsumoto T, Uefuji A, Matsushita T, Takayama K, Araki D, Nakano N, Nagai K, Matsuzaki T, Kuroda R, Kurosaka M. Anterior cruciate ligament remnant tissue harvested within 3-months after injury predicts higher healing potential. BMC Musculoskelet Disord 16(1): 390, 2015

(36) Takayama K, Kawakami Y, Lee S, Greco N, Lavasani M, Mifune Y, Cummins JH, Yurube T, Kuroda R, Kurosaka M, Fu FH, Huard J. Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. J Orthop Res 32(10):1326-32, 2014

(37) Matsuzaki T, Matsushita T, Tabata Y, Saito T, Matsumoto T, Nagai K, Kuroda R, Kurosaka M. Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model. Biomaterials 35(37):9904-11, 2014

(38) Oka S, Matsushita T, Kubo S, Matsumoto T, Tajimi H, Kurosaka M, Kuroda R. Simulation of the optimal femoral insertion site in medial patellofemoral ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 22(10):2364-71, 2014

(39) Araki D, Kuroda R, Matsumoto T, Nagamune K, Matsushita T, Hoshino Y, Oka S, Nishizawa Y, Kurosaka M. Three-dimensional analysis of bone tunnel changes after anatomic double-bundle anterior cruciate ligament reconstruction using multidetector-row computed tomography. Am J Sports Med 42(9):2234-41, 2014

(40) Morishita M, Ishida K, Matsumoto T, Kuroda R, Kurosaka M, Tsumura N. Intraoperative platelet-rich plasma does not improve outcomes of total knee arthroplasty. J Arthroplasty 29(12):2337-41, 2014

(41) Chinzei N, Ishida K, Kuroda R, Matsumoto T, Kubo S, Iguchi T, Chin T, Akisue T, Nishida K, Kurosaka M, Tsumura N. Tibial tubercle osteotomy with screw fixation for total knee arthroplasty. Orthopedics 37(4):e367-73, 2014

(42) Uefuji A, Matsumoto T, Matsushita T, Ueha T, Zhang S, Kurosaka M, Kuroda R. Age-Related Differences in Anterior Cruciate Ligament Remnant Vascular-Derived Cells. Am J Sports Med 42(6):1478-1486, 2014

(43) Matsushita T, Kuroda R, Oka S, Matsumoto T, Takayama K, Kurosaka M. Clinical outcomes of medial patellofemoral ligament reconstruction in patients with an increased tibial tuberosity-trochlear groove distance. Knee Surg Sports Traumatol Arthrosc 22(10):2438-44, 2014

(44) Matsumoto T, Kuroda R, Matsushita T, Araki D, Hoshino Y, Nagamune K, Kurosaka M. Reduction of tunnel enlargement with use of autologous ruptured tissue in anterior cruciate ligament reconstruction: a pilot clinical trial. Arthroscopy 30(4):468-74, 2014

(45) Nishizawa Y, Matsumoto T, Araki D, Nagamune K, Matsushita T, Kurosaka M, Kuroda R. Matching articular surfaces of selected donor and recipient sites for cylindrical osteochondral grafts of the femur: quantitative evaluation using a 3-dimensional laser scanner. Am J Sports Med 42(3):658-64, 2014

(46) Chinzei N, Ishida K, Tsumura N, Matsumoto T, Kitagawa A, Iguchi T, Nishida K, Akisue T, Kuroda R, Kurosaka M. Satisfactory results at 8 years mean follow-up after ADVANCER medial-pivot total knee arthroplasty. Knee 21(2):387-90, 2014

(47) Kuroda R, Matsumoto T, Kawakami Y, Fukui T, Mifune Y, Kurosaka M. Clinical impact of circulating CD34-positive cells on bone regeneration and healing. Tissue Eng Part B Rev 20(3):190-9, 2014

(48) Kuroda R, Matsumoto T, Niikura T, Kawakami Y, Fukui T, Lee SY, Mifune Y, Kawamata S, Fukushima M, Asahara T, Kawamoto A, Kurosaka M. Local transplantation of granulocyte colony stimulating factor-mobilized CD34+ cells for patients with femoral and tibial nonunion: pilot clinical trial. Stem Cells Transl Med 3(1):128-34, 2014

(49) Matsumoto T, Muratsu H, Kawakami Y, Takayama K, Ishida K, Matsushita T, Akisue T, Nishida K, Kuroda R, Kurosaka M. Soft-tissue balancing in total knee arthroplasty: cruciate-retaining versus posterior-stabilised, and measured-resection versus gap technique. Int Orthop. 38(3):531-7, 2014

(50) Sasaki H, Ishida K, Shibanuma N, Tei K, Tateishi H, Toda A, Yamashiro Y, Matsumoto T, Kuroda R, Kurosaka M. Retrospective comparison of three thromboprophylaxis agents, edoxaban, fondaparinux, and enoxaparin, for preventing venous thromboembolism in total knee arthroplasty. Int Orthop 38(3):525-9, 2014

(51) Nagai K, Muratsu H, Matsumoto T, Miya H, Kuroda R, Kurosaka M. Soft tissue balance changes depending on joint distraction force in total knee arthroplasty. J Arthroplasty 29(3):520-4, 2014

(52) Matsuzaki T, Matsumoto T, Kubo S, Muratsu H, Matsushita T, Kawakami Y, Ishida K, Oka S, Kuroda R, Kurosaka M. Tibial internal rotation is affected by lateral laxity in cruciate-retaining total knee arthroplasty: an intraoperative kinematic study using a navigation system and offset-type tensor. Knee Surg Sports Traumatol Arthrosc. 22(3):615-20, 2014

(53) Chinzei N, Ishida K, Matsumoto T, Kuroda Y, Kitagawa A, Kuroda R, Akisue T, Nishida K, Kurosaka M, Tsumura N. Evaluation of patellofemoral joint in ADVANCE Medial-pivot total knee arthroplasty. Int Orthop. 38(3):509-15, 2014

(54) Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann Rheum Dis 73(7):1397-404, 2014

(55) Oka S, Matsumoto T, Muratsu H, Kubo S, Matsushita T, Ishida K, Kuroda R, Kurosaka M. The influence of the tibial slope on intra-operative soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 22(8):1812-8, 2014

(56) Ishida K, Matsumoto T, Tsumura N, Iwakura T, Kubo S, Iguchi T, Akisue T, Nishida K, Kurosaka M, Kuroda R. No difference between double-high insert and medial-pivot insert in TKA. Knee Surg Sports Traumatol Arthrosc. 22(3):576-80, 2014

(57) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kurosaka M, Kuroda R. Joint gap kinematics in unicompartmental knee arthroplasty. Clin Biomech 28(1):29-33, 2013

(58) Mifune Y, Ota S, Takayama K, Hoshino Y, Matsumoto T, Kuroda R, Kurosaka M, Fu FH, Huard J. Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: Results in an animal model. Am J Sport Med 41(2):365-73, 2013

(59) Nishizawa Y, Matsumoto T, Kubo S, Muratsu H, Matsushita T, Oka S, Ishida K, Matsuzaki T, Nishida K, Akisue T, Kuroda R, Kurosaka M. The influence of the patella height on soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty. Int Orthop 37:421-5, 2013

(60) Matsushita T, Sasaki H, Takayama K, Ishida K, Matsumoto T, Kubo S, Matsuzaki T, Nishida K, Kurosaka M, Kuroda R. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes. J Orthop Res 31(4):531-7, 2013

(61) Oka S, Matsumoto T, Matsushita T, Kubo S, Sasaki H, Nishizawa Y, Matsuzaki T, Tabata Y, Kurosaka M, Kuroda R. Local administration of low dose simvastatin-conjugated gelatin hydrogel for tendon-bone healing in anterior cruciate ligament reconstruction. Tissue Eng 19(9-10):1233-43, 2013

(62) Matsuzaki T, Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kawakami Y, Ishida K, Oka S, Kuroda R, Kurosaka M. Kinematic factors affecting postoperative knee flexion after cruciate-retaining total knee arthroplasty. Int Orthop 37(5):803-8, 2013

(63) Mifune Y, Matsumoto T, Ota S, Meszauos LB, Gao X, Li H, Usas A, Gharaibeh B, Fu FH, Huard J. The Effect of Platelet-Rich Plasma on the Regenerative Therapy of Muscle Derived Stem Cells for Articular Cartilage Repair. Osteoarthritis Cartilage 21(1):175-85, 2013

(64) Mifune Y, Matsumoto T, Takayama K, Terada S, Sekiya N, Kuroda R, Kurosaka M, Fu FH, Huard J. Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction. Biomaterials 34(22):5476-87, 2013

(65) Araki D, Kuroda R, Matsushita T, Matsumoto T, Kubo S, Nagamune K, Kurosaka M. Biomechanical analysis of the knee with partial anterior cruciate ligament disruption: Quantitative evaluation using an electromagnetic measurement system. Arthroscopy 29(6):1053-62, 2013

(66) Mifune Y, Matsumoto T, Murasawa S, Kuroda R, Kawamoto A, Shoji T, Kuroda T, Kurosaka M, Asahara T. Potential of CD271+ Derived Stromal Cells for Cartilage Repair. Cell Transplant 22(7):1201-11, 2013

(67) Araki D, Kuroda R, Matsumoto T, Nagamune K, Matsushita T, Kubo S, Oniki Y, Kurosaka M. An Analysis of Surface Profile for Cylindrical Osteochondral Grafts of the Knee -Quantitative Evaluation using a Three-Dimentional Laser Scanner-. Knee Surg Sports Traumatol Arthrosc 21(8):1794-800, 2013

(68) Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Kuroda R, Akimaru H, Mifune Y, Shoji T, Fukui T, Asahi M, Kurosaka M, Asahara T. A Small Interfering RNA Targeting Lnk Accelerates Bone Fracture Healing with Early Neovascularization. Lab Invest 93(9): 1036-53, 2013

(69) Nakano N, Matsumoto T, Ishida K, Tsumura N, Kuroda R, Kurosaka M. Long-term subjective outcomes of computer-assisted total knee arthroplasty. Int Orthop 37(10): 1911-5, 2013

(70) Matsumoto T, Kubo S, Muratsu H, Matsushita T, Ishida K, Kawakami Y, Oka S, Matsuzaki T, Kuroda Y, Nishida K, Akisue T, ,Kuroda R, Kurosaka M. Different pattern in gap balancing between the cruciate-retaining and posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 21(10): 2338-45, 2013

(71) Nagai K, Muratsu H, Matsumoto T, Kubo S, Maruo A, Miya H, Kuroda R, Kurosaka M. Influence of intra-operative soft tissue balance on post-operative early recovery of active knee flexion in posterior-stabilized total knee arthroplasty. Int Orthop 37(11):2153-7, 2013

(72) Osawa A, Harner C, Gharaibeh B, Matsumoto T, Mifune Y, Kopf S, Ingham SM, Schreiber V, Usas A, Huard J*. The Use of Blood Vessel-Derived Stem Cells for Meniscal Regeneration and Repair. Med Sci Sports Exerc 45(5):813-23, 2013

(73) Okamoto J, Matsumoto T, Muratsu H, Kurosaka M, Muragaki Y, Iseki H. Robotic tensor device for optimal soft tissue balance in TKA. Conf Proc IEEE Eng Med Biol Soc 6695-8, 2013

(74) Okamoto J, Kumasaka Y, Kawamura K, Matsumoto T, Kubo S, Muratsu H, Kurosaka M, Fujie MG. Study of Anatomical Landmark Sampling Error Effect on Motion Measurement Reproducibility for Orthopaedic Physical Examination Assisting System. Journal of Advanced Mechanical Design, Systems, and Manufacturing

(75) Takayama K, Matsumoto T, Kubo S, Muratsu H, Ishida K, Matsushita T, Kurosaka M, Kuroda R. The Influence of Intra-operative Joint Gap on Post-operative Flexion Angle in Cruciate-retaining Total Knee Arthroplasty. Knee Surg Sports Traumatol Arthrosc 20(3): 532-7, 2012

(76) Kuroda R, Hoshino Y, Araki D, Nishizawa Y, Nagamune K, Matsumoto T, Kubo S, Matsushita T, Kurosaka M. Quantitative measurement of the pivot shift, reliability, and clinical applications. Knee Surg Sports Traumatol Arthroscopy 20(4):686-91, 2012

(77) Matsumoto T, Muratsu H. In Reply; Physiologic knee condition in assessing intraoperative soft tissue balance in total knee arthroplasty. J Arthroplasty 27(4):655-6, 2012

(78) Fujita N, Matsushita T, Ishida K, Sasaki K, Kubo S, Matsumoto T, Kurosaka M, Tabata Y, Kuroda R. An analysis of bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable sponge composed of gelatin and β-tricalcium phosphate. J Tissue Eng Regen Med 6(4):291-8, 2012

(79) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Ishida K, Sasaki H, Oka S, Kurosaka M, Kuroda R. Soft tissue balance using tibia first gap technique with navigation system in cruciate-retaining total knee arthroplasty. Int Orthop 36: 975-80, 2012

(80) Matsumoto T, Ingham SM, Mifune Y, Osawa A, Logor A, Usas A, Kuroda R, Kurosaka M, Fu FH, Huard J. Isolation and Characterization of Anterior Cruciate Ligament Derived Stem Cells. Stem Cells Dev 21(6):859-72, 2012

(81) Matsumoto T, Kubo S, Sasaki K, Kawakami Y, Oka S, Sasaki H, Takayama K, Tei K, Matsushita T, Mifune Y, Kurosaka M, Kuroda R. Acceleration of tendon-bone healing of anterior cruciate ligament graft using autologous ruptured tissue. Am J Sport Med 40(6): 1296-1302, 2012

(82) Sasaki H, Takayama K, Matsushita T, Ishida K, Kubo S, Matsumoto T, Fujita N, Oka S, Kurosaka M, Kuroda R. Autophagy modulates osteoarthritis-related gene expressions in human chondrocytes. Arthritis Rheum 64(6): 1920-8, 2012

(83) Fukui T, Ii M, Shoji T, Matsumoto T, Mifune Y, Kawakami Y, Akimaru H, Kawamoto A, Kuroda T, Saito T, Tabata Y, Kuroda R, Kurosaka M, Asahara T. Therapeutic Effect of Local Administration of Low Dose Simvastatin-conjugated Gelatin Hydrogel for Fracture Healing. J Bone Min Res 27(5):1118-31, 2012

(84) Kawakami Y, Hiranaka T, Matsumoto T, Hida Y, Uemoto H, Tsuji M, Kuroda R, Kurosaka M. Clinical Values of Fluorescopic-Based Navigation System for Anterior Cruciate Ligament Reconstruction. Knee Surg Sports Traumatol Arthrosc 20(8):1503-10, 2012

(85) Oka S, Muratsu H, Matsumoto T, Kubo S, Maruo A, Miya H, Kuroda R, Kurosaka M. The Influence of Patellar Orientation on Soft Tissue Balance in Minimally Incision Total Knee Arthroplasty. Knee Surg Sports Traumatol Arthrosc 20(6):1064-8, 2012

(86) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kurosaka M, Kuroda R. Intra-operative soft tissue balance reflects minimum 5-year mid-term outcomes in cruciate-retaining and posterior-stabilized total knee arthroplasty. J Arthroplasty 27(9):1723-30, 2012

(87) Ishida K, Matsumoto T, Tsumura N, Chinzei N, Kitagawa A, Kubo S, Chin T, Iguchi T, Akisue T, Nishida K, Kurosaka M, Kuroda R. In vivo comparisons of patellofemoral kinematics before and after ADVANCE Medial-Pivot total knee arthroplasty. Int Orthop 36(10): 2073-7, 2012

(88) Fukui T, Matsumoto T, Mifune Y, Shoji T, Kuroda T, Kawakami Y, Kawamoto A, Ii M, Kurosaka M, Asahara T, Kuroda R. Local Transplantation of Granulocyte Colony Stimulating Factor-Mobilized Human Peripheral Blood Mononuclear Cells for Unhealing Bone Fracture. Cell Transplant 21(4):707-21, 2012

(89) Kawakami Y, Ii M, Alev C, Kawamoto A, Matsumoto T, Kuroda R, Shoji T, Fukui T, Masuda H, Akimaru H, Mifune Y, Kuroda T, Horii M, Yokoyama A, Kurosaka M, Asahara T. Local Transplantation of Ex-vivo Expanded Bone Marrow-derived CD34 positive Cells Accelerate Fracture Healing. Cell Transplant 21(12):2689-709, 2012

(90) Lee YH, Kuroda R, Zhao J, Chan KM. A tale of 10 European centres - 2010 APOSSM travelling fellowship review in ACL surgery. Sports Med Arthrosc Rehabil Ther Technol. 2012 Jul 28;4(1):27. doi: 10.1186/1758-2555-4-27.

(91) Nishimori M, Matsumoto T, Ota S, Kopf S, Mifune Y, Harner C, Ochi M, Fu FH, Huard J. Role of angiogenesis after muscle derived stem cell transplantation in injured medial collateral ligament. J Orthop Res 30(4): 627-33, 2012

(92) Fadini GP, Rattazzi M, Matsumoto T, Asahara T, Khosla S. Emerging Role of Circulating Cells in the Bone-Vascular Axis. Circulation 125(22): 2772-81, 2012

(93) Atesok K, Matsumoto T, Asahara T, Karlsson J, Doral MN, Verdonk R, Li R, Schemitsch EH. An Emerging Strategy in Cell-Based Therapies: Endothelial Progenitor Cells. Knee Surg Sports Traumatol Arthrosc 20(7):1366-77, 2012

(94) Ishida K, Tsumura N, Kitagawa A, Hamamura S, Fukuda K, Dogaki Y, Kubo S, Matsumoto T, Matsushita T, Chin T, Iguchi T, Kurosaka M, Kuroda R. Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty. Int Orthop 35(11):1639-45, 2011.

(95) Matsumoto T, Kubo S, Muratsu H, Tsumura N, Ishida K, Matsushita T, Takayama K, Sasaki H, Oka S, Kurosaka M, Kuroda R. Differing prosthetic alignment and femoral component sizing between 2 computer-assisted CT-free navigation system in TKA. Orthopedics 34(12): e860-5, 2011.

(96) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kurosaka M, Kuroda R. The Influence of Pre-operative Deformity on Intra-operative Soft Tissue Balance in Posterior-Stabilized Total Knee Arthroplasty. J Arthroplasty 26(8):1291-8, 2011.

(97) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kurosaka M, Kuroda R. Soft-tissue tension in cruciate-retaining and posterior-stabilized total knee arthroplasty. J Arthroplasty 26(5): 788-95, 2011.

(98) Araki D, Kuroda R, Kubo S, Nagamune K, Hoshino Y, Nishimoto K, Takayama K, Matsushita T, Tei K, Yamaguchi M, Kurosaka M. The use of an electromagnetic measurement system for anterior tibial displacement during the Lachman test. Arthroscopy 27(6):792-802, 2011.

(99) Fujita N, Kuroda R, Matsumoto T, Yamaguchi M, Yagi M, Matsumoto A, Kubo S, Matsushita T, Hoshino Y, Nishimoto K, Araki D, Kurosaka M. Comparison of the Clinical Outcome of Double-Bundle, Anteromedial Single-Bundle, and Posterolateral Single-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendon Graft With Minimum 2-Year Follow-Up. Arthroscopy 27(7):906-13, 2011.

(100) Ishida K, Matsumoto T, Tsumura N, Kubo S, Kitagawa A, Iguchi T, Kurosaka M, Kuroda R. Mid-term outcomes of computer-assisted total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 19(7): 1107-12, 2011.

(101) Matsumoto T, Muratsu H, Kubo S, Mizuno K, Kinoshita K, Ishida K, Matsushita T, Sasaki K, Tei K, Takayama K, Sasaki H, Oka S, Kurosaka M, Kuroda R. Soft tissue balance measurement in minimal incision surgery compared to conventional total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 19(6): 880-6, 2011.

(102) Araki D, Kuroda R, Kubo S, Fujita N, Tei K, Nishimoto K, Hoshino Y, Matsushita T, Matsumoto T, Nagamune K, Kurosaka M. A prospective randomised study of anatomical single-bundle versus double-bundle anterior cruciate ligament reconstruction: quantitative evaluation using an electromagnetic measurement system. Int Orthop 35(3):439-46, 2011.

(103) Fujita N, Matsushita T, Ishida K, Kubo S, Matsumoto T, Takayama K, Kurosaka M, Kuroda R. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J Orthop Res 29(4):511-5, 2011.

(104) Kuroda T, Matsumoto T, Mifune Y, Fukui T, Kubo S, Matsushita T, Asahara T, Kurosaka M, Kuroda R. Therapeutic strategy of third generation autologous chondrocyte implantation for osteoarthritis. Upsala J Med Sci 116(2):107-14, 2011.

(105) Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A, Matsumoto T, Suehiro S, Carmeliet P, Asahara T. PlGF Repairs Myocardial Ischemia Through Mechanisms of Angiogenesis, Cardioprotection and Recruitment of Myo-angiogenic Competent Marrow Progenitors. PLos One 6(9): e24872, 2011

(106) Okamoto J, Kumasaka Y, Kawamura K, Matsumoto T, Kubo S, Muratsu H, Kurosaka M, Fujie MG. Orthopaedic Physical Examination Assisting System for Improvement of Accuracy and Reproducibility of Knee Laxity Diagnosis. Journal of Advanced Mechanical Design, Systems, and Manufacturing 5(4): 358-71, 2011

(107) Li G, Zheng B, Meszaros LB, Vellas JB, Usas A, Matsumoto T, Huard J. Identification and characterization of chondrogenic progenitor cells in the fascia of postnatal skeletal muscle. J Mol Cell Biol 3(6):369-77, 2011

英文症例報告(2012年以降)

(1) Tsujimoto R, Matsumoto T, Takayama K, Kawakami Y, Kamimura M, Matsushita T, Kuroda R, Kurosaka M. Acute Popliteal Artery Occlusion after Revision Total Knee Arthroplasty. Case Rep Orthop 672164, 2015

(2) Kuroda Y, Matsushita T, Matsumoto T, Kawakami Y, Kurosaka M, Kuroda R. Bilateral medial patellofemoral ligament reconstruction in high-level athletes. Knee Surg Sports Traumatol Arthrosc. 22(10):2465-9, 2014

(3) Matsushita T, Kuroda R, Araki D, Kubo S, Matsushita T, Matsumoto T, Kurosaka M. Medial patellofemoral ligament reconstruction with lateral soft tissue release in adult patients with habitual patellar dislocation. Knee Surg Sports Traumatol Arthrosc 21(3):726-30, 2013

(4) Fujita N, Matsumoto T, Kubo S, Matsushita T, Ishida K, Hoshino Y, Nishimoto K, Kurosaka M, Kuroda R. Autologous osteochondral graft transplantation for steroid-induced osteonecrosis of the femoral condyle: A report of three young cases. Sports Med Arthrosc Rehabil Ther Technol 4(1):13, 2012

(5) Nagai K, Matsumoto T, Matsushita T, Kubo S, Takayama K, Araki D, Sasaki H, Oka S, Akisue T, Kurosaka M, Kuroda R. Spontaneous Recurrent Hemarthrosis of the Knee Joint in the Elderly. A Report of Two Cases. J Orthop Sci 17(5): 649-53, 2012

(6) Minoda M, Matsumoto T, Kubo S, Matsushita T, Takayama K, Kurosaka M, Kuroda R. Multiple huga subchondral cysts associated with pseudogout in the bilateral knees: A case report and review of the literature. J Orthop Sci 17(6): 817-21, 2012

(7) Niikura T, Lee SY, Matsumoto T, Fukui T, Kawakami Y, Akisue T, Kuroda R, Kurosaka M. Backout of the helical blade of proximal femoral nail antirotation and accompanying fracture nonunion. Orthopedics 35(8): e1264-6, 2012

(8) Matsuzaki T, Akisue T, Kishimoto K, Kishimoto S, Imabori M, Hara H, Okada Y, Hitora T, Kuroda R, Kurosaka M, Yamamoto T. Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis. Rheumatol Int 32(6):1691-4, 2012.

(9) Tei K, Kubo S, Matsumoto T, Matsushita T, Matsumoto A, Kurosaka M, Kuroda R. Combined osteochondral fracture of the posterolateral tibial plateau and Segond fracture with anterior cruciate ligament injury in a skeletally immature patient. Knee Surg Sports Traumatol Arthrosc 20(2):252-5, 2012.

英文著書(2012年以降)

(1) Matsumoto T, Kuroda R. Strategies to Enhance Biological Tendon-Bone Healing in Anterior Cruciate Ligament Reconstruction. ACL Injury and Its Treatment Ochi M, Shino K, Yasuda K, Kurosaka M (Eds), Springer, 537-548, 2016

(2) Matsumoto T, Kuroda R. Causes of Pain After Total Knee Replacement -Malposition and Malorientation after Total Knee Replacement-. The Unhappy Total Knee Replacement: A Comprehensive Review and Management Guide. Michael Hirschmann, Roland Becker (Ed), Springer. 165-73, 2015

(3) Zhang S., Oka S., Kuroda R. and Kurosaka M. Anatomy and Biomechanics of Medial Patellofemoral Ligament In: The Patellofemoral Joint -State of the Art in Evaluation and Management-. Springer Berlin Heidelberg. 17-22, 2014

(4) Matsumoto T, Asahara T. Endothelial progenitor cells, Lnk and bone fracture healing. Stem Cells and Bone Tissue Rajkumar Rajendram (Ed), Science Publishers CRC Press, 180-99, 2013

(5) Matsumoto T, Muratsu H, Kubo S, Kurosaka M, Kuroda R. Soft Tissue Balance in Total Knee Arthroplasty, Recent Advances in Hip and Knee Arthroplasty, Samo K. Fokter (Ed.), ISBN: 978-953-307-841-0, InTech, 2012.

(6) Matsumoto T, Muratsu H, Kubo S, Matsushita T, Kuroda R, Kurosaka M. Soft tissue balancing with navigation system. Soft Tissue Balancing in Primary Total Knee Arthroplasty, Roberto Rossi (Ed.), Edizioni Minerva Medica Spa, 33-39, 2012.

 
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